Cardiovascular system is a system that allows the circulation of blood and transports nutrients and oxygen within the body. Its main components are the heart, blood and blood vessels. It performs pulmonary and systemic circulation. Pulmonary circulation refers to a loop through the lungs where oxygenated blood is present and systemic circulation is a loop through the whole body to provide oxygenated blood. The systemic circulation functions in two parts, namely, macrocirculation and microcirculation. In humans, blood never leaves the network of blood vessels. This type of cardiovascular system is known as closed cardiovascular system. Some of the major diseases which affect the cardiovascular system are arrythmias, congenital heart disease, heart failure and heart attack. This book provides significant information of this discipline to help develop a good understanding of the cardiovascular system. It elucidates the concepts and innovative models around prospective developments with respect to redox and nitrosative signalling. This book is meant for students who are looking for an elaborate reference text on cardiovascular system.