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Cellular and Animal Models in Human Genomics Research: Translational and Applied Genomics

Katherina Walz, Juan I. Young
en Limba Engleză Paperback – 30 iul 2019
Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals.
Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth.


  • Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies
  • Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health
  • Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms
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Specificații

ISBN-13: 9780128165737
ISBN-10: 0128165731
Pagini: 226
Ilustrații: 60 illustrations (20 in full color)
Dimensiuni: 191 x 235 mm
Greutate: 0.48 kg
Editura: ELSEVIER SCIENCE
Seria Translational and Applied Genomics


Public țintă

Active researchers, basic and translational scientists, clinicians, postgraduates, and students in the areas of genetics, human genomics, pathology, cellular biology, organismal biology, molecular biology, biochemistry, and bioinformatics

Cuprins

1. Introduction to human genetics
2. Disease in a dish: Cellular models to understand human conditions
3. Tiny models to answer big questions: The worm and the yeast as tools in human genetics research
4. Understanding human genetic disease with the fly
5. Studying human genetic variation in zebrafish
6. The mouse, a key model organism for biomedical research
7. Crispr/Cas technology
8. Integrative modeling and novel technologies in human genomics
9. Models to understand human genomics, final considerations