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Chemical and Structural Approaches to Rational Drug Design: Handbooks in Pharmacology and Toxicology

Editat de David B. Weiner, William V. Williams
en Limba Engleză Hardback – 28 noi 1994
This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
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Specificații

ISBN-13: 9780849378188
ISBN-10: 0849378184
Pagini: 290
Ilustrații: 18 Halftones, black and white; 44 Tables, black and white; 18 Illustrations, black and white
Dimensiuni: 178 x 254 x 19 mm
Greutate: 0.68 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Handbooks in Pharmacology and Toxicology

Locul publicării:Boca Raton, United States

Public țintă

Professional

Cuprins

Section I: Chemical Approaches to Rational Drug Design 1. Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase 2. The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors 3. The Development of Potent Angiotensin II Receptor Antagonists Using a Novel Peptide Pharmacophore Model 4. Endothelin Structure and Development of Receptor Antagonists 5. Molecular Targeting Chemistry in Rational Drug Design Section II: Structural Approaches to Rational Drug Design 6. The Role of X-Ray Crystallography in Structure-Based Rational Drug Design 7. Biocomputational Approaches to Protein-Based Drug Design 8. Architecture and Design of Zinc Protein-Ligand Complexes 9. Design of Immunomodulatory Peptides Based on Active Site Structures

Notă biografică

Weiner\, David B.; Williams\, William V.

Descriere

This book deals with predominantly synthetic chemical approaches to drug design and explores the use of structure-activity relationships in the design of novel inhibitors of ribonucleotide reductase. It describes the application of the tools of structural biology to pharmaceutical development.