Chromosome Translocation: Advances in Experimental Medicine and Biology, cartea 1044
Editat de Yu Zhangen Limba Engleză Hardback – 18 iul 2018
The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation.
It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.
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Specificații
ISBN-13: 9789811305924
ISBN-10: 9811305927
Pagini: 170
Ilustrații: V, 168 p. 29 illus., 27 illus. in color.
Dimensiuni: 178 x 254 x 11 mm
Greutate: 0.55 kg
Ediția:1st ed. 2018
Editura: Springer Nature Singapore
Colecția Springer
Seria Advances in Experimental Medicine and Biology
Locul publicării:Singapore, Singapore
ISBN-10: 9811305927
Pagini: 170
Ilustrații: V, 168 p. 29 illus., 27 illus. in color.
Dimensiuni: 178 x 254 x 11 mm
Greutate: 0.55 kg
Ediția:1st ed. 2018
Editura: Springer Nature Singapore
Colecția Springer
Seria Advances in Experimental Medicine and Biology
Locul publicării:Singapore, Singapore
Cuprins
Chapter 1: Historical and clinical overview of chromosome translocations.- Chapter 2: Next generation sequencing to identify chromosome translocation.- Chapter 3: The experimental models to study chromosome translocations.- Chapter 4: High throughput translocation sequencing to identify mechanistic factors shaping translocatome.- Chapter 5: Live cell imaging to study chromosome translocation.- Chapter 6: CRISPR/Cas9 to induce chromosome translocation in vivo.- Chapter 7: Generation of DNA double strand breaks (DSBs).- Chapter 8: The role of DSB response pathway in regulating chromosome translocation.- Chapter 9: DSB repair and ligation of chromosome translocation.- Chapter 10: 3D genome organization defines the chromosome translocation pattern.- Chapter 11: Mechanisms of chromosome deletion.- Chapter 12: Chromothripsis: The role of DNA double strand break form on repair pathway selection.
Notă biografică
Dr. Yu Zhang is Assistant Investigator at National Institute of Biological Sciences, Beijing, China.
Textul de pe ultima copertă
This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases.
The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation.
It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.
The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation.
It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.
Caracteristici
Introduces mechanisms and methodologies of chromosome translocations Provides a clear overview of the basics Reviews up-to-date knowledge of chromosome translocations Contributions from experts in the field