This report explains the accident involving Corporate Airlines flight 5966, a BAE Systems BAE-J3201, N875JX, that crashed short of the runway on approach to land at Kirksville Regional Airport, Kirksville, Missouri. Safety issues in this report focus on operational and human factors issues, including the pilots' professionalism and sterile cockpit procedures, nonprecision instrument approach procedures, flight and duty time regulations, fatigue, and flight data/image recorder requirements.