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Coordinating Organismal Physiology Through the Unfolded Protein Response de R. Luke Wiseman

Coordinating Organismal Physiology Through the Unfolded Protein Response: Current Topics in Microbiology and Immunology, cartea 414

Editat de R. Luke Wiseman, Cole M. Haynes
en Limba Engleză Hardback – 27 apr 2018
This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike.

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Specificații

ISBN-13: 9783319785295
ISBN-10: 331978529X
Pagini: 220
Ilustrații: VII, 213 p.
Dimensiuni: 155 x 235 x 20 mm
Greutate: 0.49 kg
Ediția:1st ed. 2018
Editura: Springer International Publishing
Colecția Springer
Seria Current Topics in Microbiology and Immunology

Locul publicării:Cham, Switzerland

Cuprins

Adapting Secretory Proteostasis and Function Through the Unfolded Protein Response.- Cell Non-Autonomous UPRER Signaling.- The unfolded protein response in the immune cell development: Putting the caretaker in the driving seat.- Mitochondria associated membranes and ER stress.- Coordinating Organismal Metabolism during Protein Misfolding in the ER Through the Unfolded Protein Response.- ER stress and neurodegenerative disease: a cause or effect relationship?- Driving cancer tumorigenesis and metastasis through UPR signaling.- ER Protein Quality Control and the Unfolded Protein Response in the Heart.



Notă biografică

R. Luke Wiseman

Associate Professor
Department of Molecular Medicine
The Scripps Research Institute MEM 220
La Jolla, CA 92037, USA

Phone: (858) 784-8820
Email: wiseman@scripps.edu
Cole M. Haynes
Associate Professor
University of Massachusetts Medical School
Worcester, MA 01605, USA
Email:Cole.Haynes@umassmed.edu


Textul de pe ultima copertă

This volume reviews the current research focused on the functional importance of unfolded protein response (UPR) signaling in the context of health and disease. The chapters present cutting-edge work describing the diverse functions of UPR signaling critical for regulating cellular and organismal physiology under physiologic and pathologic conditions. Written by internationally respected scientists, this volume is designed to provide a broad view of the diverse functional importance of UPR, and as such appeals to clinicians and academic researchers alike.

Caracteristici

Highlights the importance of UPR signaling in regulating endoplasmic reticulum function Examines how imbalances in UPR signaling can influence human disease pathogenesis Discusses therapeutic potential for UPR-dependent remodeling of ER proteostasis to intervene in etiologically diverse human diseases