This volume constitutes refereed proceedings of the 5th International Conference on Digital Transformation and Global Society, DTGS 2020, held in St. Petersburg, Russia, in June 2020. Due to the COVID-19 pandemic the conference was held online.  The 30 revised full papers and 6 short papers presented in the volume were carefully reviewed and selected from 108 submissions. The papers are organized in topical sections on ​e-society: virtual communities and online activism; e-society: computational social science; e-polity: governance and politics on the Internet; e-city: smart cities and urban governance; e-economy: digital economy and consumer behavior; e-humanities: digital culture and education; e-health: international workshop "E-Health: 4P-medicine & Digital Transformation".