This guidebook presents historical and new material to assist the reader to understand NFL game strategies and provides a winning betting strategy. The authors, William Ziemba and Leonard MacLean are professors, traders, financial analysts and sports enthusiasts. They covered ideas like the game's strategies, and shared their wealth of personal experience analyzing the regular season, the playoffs and the Super Bowls in the years 2010-2017. The results of their actual betting for the 2009-10 to the 2017-18 seasons are provided. The authors concluded the book with a forecast for the 2018-2019 season. They determine the players most valuable to win the games, discuss crucial decisions and provide prediction methodology. The authors concluded with a forecast of the top teams, players and odds to win the 53rd Super Bowl.