This book constitutes the refereed proceedings of the 8th International Conference on Intelligent Computing, ICIC 2012, held in Huangshan, China, in July 2012.The 242 revised full papers presented in the three volumes LNCS 7389, LNAI 7390, and CCIS 304 were carefully reviewed and selected from 753 submissions. The papers in this volume (CCIS 304) are organized in topical sections on Neural Networks; Particle Swarm Optimization and Niche Technology; Kernel Methods and Supporting Vector Machines; Biology Inspired Computing and Optimization; Knowledge Discovery and Data Mining; Intelligent Computing in Bioinformatics; Intelligent Computing in Pattern Recognition; Intelligent Computing in Image Processing; Intelligent Computing in Computer Vision; Intelligent Control and Automation; Knowledge Representation/Reasoning and Expert Systems; Advances in Information Security; Protein and Gene Bioinformatics; Soft Computing and Bio-Inspired Techiques in Real-World Applications; Bio-Inspired Computing and Applications.