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Environmental Epigenetics in Toxicology and Public Health: Translational Epigenetics, cartea 22

Editat de Rebecca Fry Trygve O Tollefsbol
en Limba Engleză Paperback – 22 oct 2020
Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects.
This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures.


  • Offers a thorough discussion of the environmental factors influencing epigenetic mechanisms in early and late life, and in transgenerational inheritance
  • Examines both animal model and human population-based research in environmental epigenetics, highlighting developmental windows of vulnerability to epigenetic modification
  • Features contributions from international experts in the field
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Specificații

ISBN-13: 9780128199688
ISBN-10: 0128199687
Pagini: 364
Ilustrații: 60 illustrations (30 in full color)
Dimensiuni: 191 x 235 mm
Greutate: 0.72 kg
Editura: ELSEVIER SCIENCE
Seria Translational Epigenetics


Public țintă

Human geneticists; human genomicists; translational researchers in genomic medicine, epigenetics, molecular biology, toxicology, public health, environmental science; life science researchers; oncologists; immunologists; bioengineers; developmental biologists

Cuprins

Section I. Epigenetic Mechanisms/Machinery 1. DNA methylation/chromatic regulation/non-coding RNAs 2. Tools for the assessment of epigenetic regulation
Section II. Transdisciplinary approaches for the study of environmental epigenetics 3. Model organisms and their application in environmental epigenetics 4. Epidemiological concepts in environmental epigenetics
Section III. Epigenetic programming of disease in relation to the environment 5. Pregnancy and Birth outcomes 6. Neurodevelopment outcomes 7. Cancer 8. Respiratory dysfunction 9. Immune dysfunction 10. Cardio/Metabolic disease 11. Aging
Section IV. Transgenerational epigenetic effects of the environment 12. Transgenerational effects of environmental contaminants
Section V. Epigenome-targeted therapies in environmental health science 13. Nutrition 14. Manipulation of Epigenetic machinery
Section VI. Conclusions and Future Perspectives 15. Conclusions and Future Perspectives: The environment and the epigenome

Recenzii

"This is an important entry in the Translational Epigenetic series at a time that such methods are moving from a status of novel to practice and even translational. This beautifully illustrated volume in the series will likely become useful, if not essential, for two groups -- graduate students encountering the material for the first time and seasoned professionals, often researchers, who have read about these techniques and now wish to employ them. Given the emergence of this field, I don't believe many years will pass before a second edition is necessary. This is perhaps the most essential public health book I have reviewed in some time." --© Doody’s Review Service, 2021, John T. Pierce, MBBS(MD), reviewer, expert opinion