Epigenetics of Aging and Longevity: Translational Epigenetics vol 4: Translational Epigenetics, cartea 4
Editat de Alexey Moskalev, Alexander Vaisermanen Limba Engleză Hardback – 13 noi 2017
This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.
- Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease
- Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory
- Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan
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Specificații
ISBN-13: 9780128110607
ISBN-10: 0128110600
Pagini: 544
Dimensiuni: 191 x 235 x 33 mm
Greutate: 1.29 kg
Editura: ELSEVIER SCIENCE
Seria Translational Epigenetics
ISBN-10: 0128110600
Pagini: 544
Dimensiuni: 191 x 235 x 33 mm
Greutate: 1.29 kg
Editura: ELSEVIER SCIENCE
Seria Translational Epigenetics
Public țintă
researchers, clinicians and graduate students in genomic medicine, epigenetics, and biogerontology interested in the genetics of aging and treating age-related diseasesCuprins
Section I: Epigenetic Mechanisms in Aging
1. Aging epigenetics: changes and challenges
2. Defective DNA methylation/demethylation processes define aging-dependent methylation patterns
3. S-adenosylmethionine Metabolism and Aging
4. The Epigenetic Clock and Ageing
5. The Epigenetic Regulation of Telomere Maintenance in Aging
6. Living Long and Ageing Well: Are Lifestyle factors the Epigenetic link in the Longevity Phenotype?
7. Epigenetic Biomarkers for Biological Age
8. The Role of Non-Coding RNAs in Genome Stability and Aging
9. Intra-tissue DNA methylation heterogeneity in aging
Section II. Early-life Epigenetic Programming of Aging Trajectories
10. Early Life Nutrition, Epigenetics and Altered Energy Balance Later in Life
11. Early Nutrition, Epigenetics and Human Health
12. Biological Embedding of Psychosocial Stress over the Life Course
13. Epigenetics of longevity in social insects
Section III. Epigenetics of Aging-Associated Diseases
14. Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging
15. Histone modification changes during aging: Cause or Consequence? - What we have learned about epigenetic regulation of aging from model organisms
16. Epigenetics of brain/cognitive aging
17. The role of epigenetic modifications in cardiometabolic diseases
18. Epigenetic mechanisms in osteoporosis
19. Epigenetics of Skeletal Muscle Aging
Section IV. Epigenome-targeted Therapies in Gerocscience
20. Healthy Aging and Epigenetic Drugs for Diabetes and Obesity: A Novel Perspective
21. Epigenetic Drugs for Cancer and Precision Medicine
22. Epigenetic Drug Discovery for Alzheimer’s Disease
Section V. Conclusions and Perspectives
23. Epigenetics of aging and longevity: challenges and future directions
1. Aging epigenetics: changes and challenges
2. Defective DNA methylation/demethylation processes define aging-dependent methylation patterns
3. S-adenosylmethionine Metabolism and Aging
4. The Epigenetic Clock and Ageing
5. The Epigenetic Regulation of Telomere Maintenance in Aging
6. Living Long and Ageing Well: Are Lifestyle factors the Epigenetic link in the Longevity Phenotype?
7. Epigenetic Biomarkers for Biological Age
8. The Role of Non-Coding RNAs in Genome Stability and Aging
9. Intra-tissue DNA methylation heterogeneity in aging
Section II. Early-life Epigenetic Programming of Aging Trajectories
10. Early Life Nutrition, Epigenetics and Altered Energy Balance Later in Life
11. Early Nutrition, Epigenetics and Human Health
12. Biological Embedding of Psychosocial Stress over the Life Course
13. Epigenetics of longevity in social insects
Section III. Epigenetics of Aging-Associated Diseases
14. Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging
15. Histone modification changes during aging: Cause or Consequence? - What we have learned about epigenetic regulation of aging from model organisms
16. Epigenetics of brain/cognitive aging
17. The role of epigenetic modifications in cardiometabolic diseases
18. Epigenetic mechanisms in osteoporosis
19. Epigenetics of Skeletal Muscle Aging
Section IV. Epigenome-targeted Therapies in Gerocscience
20. Healthy Aging and Epigenetic Drugs for Diabetes and Obesity: A Novel Perspective
21. Epigenetic Drugs for Cancer and Precision Medicine
22. Epigenetic Drug Discovery for Alzheimer’s Disease
Section V. Conclusions and Perspectives
23. Epigenetics of aging and longevity: challenges and future directions