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Histone Modifications in Therapy: Translational Epigenetics, cartea 20

Editat de Pedro Castelo-Branco, Carmen Jeronimo
en Limba Engleză Paperback – 21 aug 2020
Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment.
A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research.


  • Examines the use of histone modifications in disease prevention and therapy
  • Explores the role of histone modifications in cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, and inflammatory disease, among others
  • Features chapters from a broad range of international authors and disease specialists
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Specificații

ISBN-13: 9780128164228
ISBN-10: 0128164220
Pagini: 490
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Translational Epigenetics


Public țintă

Clinician-scientists; Human Geneticists; Medical Geneticists; Researchers working in genetics, biology, molecular biology, pharmaceutical science, oncology, cardiology, psychiatry, neurology, neuroscience, metabolic disorders, inflammatory and infectious disease, internal medicine, and clinical therapy; advanced undergraduate students, graduate students; pharmaceutical company and biotechnology researchers interested in drug development and therapies

Cuprins

1. Histone modifications in diseases
Section I Targeting histone modifications for cancer treatment
2. HDAC inhibitors in cancer therapy
3. HAT inhibitors in cancer therapy
4. Targeting DOT1L for mixed-lineage rearranged leukemia
5. BET mechanisms in cancer
6. Histone demethylase inhibitors and their potential in cancer treatment
7. Targeting chromatin remodelers in urological tumors
Section II Targeting histone modifications for infectious disease
8. The therapeutic potential of epigenetic manipulation during infectious diseases
9. Targeting histone deacetylases for bacterial infections
10. Targeting histone epigenetics to control viral infections
Section III Targeting histone modifications for treating other pathologies
11. Targeting histone modifications in psychotic disorders
12. Epigenetic treatment of neurodegenerative diseases
13. Histone modification as a potential preventative and therapeutic approach for cardiovascular disease
14. The potentiality of histone deacetylase inhibitors for diabetes and obesity
15. Targeting histone modifications in cancer immunotherapy
16. Epigenetic drug development for autoimmune and inflammatory diseases
17. Future perspectives for targeting histone modifications in therapy