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Enzyme Systems that Metabolise Drugs and Other Xenobiotics: Current Toxicology

Autor C Ioannides
en Limba Engleză Hardback – 22 noi 2001
This definitive reference work describes in detail the enzyme systems that participate in the metabolism of xenobiotics, particularly medicinal drugs. Each chapter focuses on a specific enzyme system, emphasising its role in the activation and detoxication of chemicals. Aspects discussed critically include:
* enzyme function in the metabolism and bioactivation of xenobiotics
* substrate specificity
* tissue distribution
* species distribution (to include laboratory animals and humans)
* hormonal regulation
* sex differences
* modulation by prior exposure to other chemicals
* age-dependent expression
* pharmacogenetics and modulation by disease.
Enzyme Systems that Metabolise Drugs and Other Xenobiotics will be essential reading for industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those concerned with the safety evaluation of chemicals, and investigating their metabolism, pharmacokinetic characteristics and toxicological properties. The nature and scope of the book will also make it attractive to the research toxicologist and to postgraduate students studying toxicology, as well as to clinicians and pharmacists.
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Specificații

ISBN-13: 9780471894667
ISBN-10: 0471894664
Pagini: 588
Dimensiuni: 152 x 229 x 34 mm
Greutate: 0.95 kg
Editura: Wiley
Seria Current Toxicology

Locul publicării:Chichester, United Kingdom

Public țintă

Primary Market – Industrial research scientists working in the fine chemicals and pharmaceutical industries, especially those dealing with safety evaluation of chemicals, and those involved in the study of the metabolism, pharmacokinetics and toxicological properties of chemicals and drugs. Industrial and academic libraries. Secondary Market – Research toxicologists, pharmacologists and postgraduate students studying toxicology, pharmacology and pharmacy at advanced level. Likely to be useful as supplementary reading on courses.

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Descriere

This reference work focuses on the enzyme systems that participate in the metabolism of chemicals and other xenobiotics, with emphasis being placed on drug metabolism. Each chapter focuses on a specific enzyme system.