Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis de Chung Yuan Liu

Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis: Advances in Experimental Medicine and Biology, cartea 281

Chung Yuan Liu

S. Chien

The International Scientific Symposium on Fibrinogen, Thrombosis, Coagulation, and Fibrinolysis was held in Academia Sinica, Taipei, Taiwan, Republic of China, on August 30 - September 1, 1989. This Symposium has provided a forum for the free exchange of information in this important and rapidly advancing research field. This proceedings volume provides a published record of 46 papers presented at the Symposium. The sponsors have exerted no influence on the scientific opinions or positions of the participants in the Symposium. It is hoped that this Symposium will stimulate further worldwide cooperation and collaboration in these vital fields for the benefit of all human kind. This volume is composed of four parts. The first part consists of 8 papers on Fibrinogen and Fibrin: Biochemistry, Molecular Biology, and Physiology. The second part contains 16 papers on Coagulation and Fibrinolysis: Biochemistry, Molecular Biology, and Physiology. The third part has 10 papers on Cardiovascular Cell Biology: Biochemistry, Molecular Biology, and Physiology. The fourth part comprises 12 papers on Clinical Studies of the Cardiovascular System: Thrombotic and Bleeding Disorders and Thrombolytic Therapy. The Author Index with addresses of all contributors and the Subject Index of all 46 papers are arranged at the end of this volume.

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Cuprins

Native Fibrin Gel Networks and Factors Influencing their Formation in Health and Disease.- The Structure and Evolution of Vertebrate Fibrinogen: A Comparison of the Lamprey and Mammalian Proteins.- Nucleotide Sequences of the Three Genes Coding for Human Fibrinogen.- On the Identity of Fibrin(ogen) Oligomers Appearing During Fibrin Polymerization.- Immunochemical Studies of A? Chain Crosslinking.- Abnormal Fibrinogens with Two Structural Defects.- Electrophoretic Characterizations of Cross-Linked Fibrinogen Derivatives in Blood and Vascular Tissue by Zonal Immobilization on Glyoxyl Agarose.- Studies on the Localization and Accessibility of Sites in Fibrin which Are Involved in the Acceleration of the Activation of Plasminogen by Tissue-Type Plasminogen Activator.- Prothrombinase: Recognition and Developments.- The Initiation of the Tissue Factor Dependent Pathway of Blood Coagulation.- Interactions Between the Contact System, Neutrophils and Fibrinogen.- A New Trisaccharide Sugar Chain Linked to a Serine Residue in the First EGF-Like Domain of Clotting Factors VII and IX and Protein Z.- Multiple Epitope Specificity of Monoclonal Antibodies to a Single Synthetic Peptide: Use in the Characterization of the GP lIb-IIIa Binding Domain of von Willebrand Factor.- Factor VII and Dietary Fat Intake.- Characterization of Snake Venom Principles Affecting Blood Coagulation and Platelet Aggregation.- Thrombin-Like Venom Enzymes: Structure and Function.- Thrombin Inhibition by Synthetic Hirudin Peptides.- Effects of Structural Modifications on the Properties of Tissue Plasminogen Activator (tPA).- Molecular Genetics of Alpha 2 Plasmin Inhibitor.- Biological Properties of Hybrid Plasminogen Activators.- The Regulation of the Activaton of the Fibrinolysis System.- The Mechanisms ofthe Activation of Plasminogen by Streptokinase and Urokinase.- Protein C and Fibrinolysis: A Link Between Coagulation and Fibrinolysis.- Transformation of Prostacyclin (PGI2) to a Biologically Active Metabolite: 5(6)-Oxido-PGI1 by Cytochrome P450-Dependent Epoxygenase.- Studies on the Localization of Fibrinogen Binding Sites on Platelet Glycoprotein IIIa.- Affinity Labeling of Nucleotide Binding Sites of Enzymes and Platelets.- The Effect of Ganodermic Acid S on Human Platelets.- Role of Insulin Receptors in the Expression of Prostaglandin E1 Binding Activity in Platelets.- Platelet-Fibrin Interaction in the Suspension and Under Flow Conditions.- An Independent Haemostatic Mechanism: Shear Induced Platelet Aggregation.- Regulation of Eicosanoid Biosynthesis in Endothelial Cells: Critical Role of De Novo Synthesis of Prostaglandin Endoperoxide Synthase.- Modulation of Endothelial Function by Hypoxia: Perturbation of Barrier and Anticoagulant Function, and Induction of a Novel Factor X Activator.- Fibrin and the Vessel Wall.- Interactions between Fibrin, Collagen and Endothelial Cells in Angiogenesis.- New Developments in Thrombolytic Therapy.- Coronary Thrombosis: Pathogenesis and Prevention.- Implications of the TIMI Trials.- Thrombotic Microangiopathy.- Clinical Trials with Alteplase (RT-pa) in Acute Myocardial Infarction.- The Effects of Streptokinase and Tissue Plasminogen Activator on Left Ventricular Function.- Modern Strategies for Treatment of Acute Myocardial Infarction: Significance of Haemostaseological and Rheological Findings.- Clinical Application of Tissue Plasminogen Activator Therapy in Acute Myocardial Infarction.- Fibrinogen Proteolysis and Coagulation System Activation During Thrombolytic Therapy.- Altered Rheological Properties of Blood Following Administrations of Tissue Plasminogen Activator and Streptokinase in Patients with Acute Myocardial Infarction.- Monoclonal Antibodies for the Detection of Thrombosis.- The Pharmacology and Clinical Pharmacology of Defibrotide: A New Profibrinolytic, Antithrombotic, and Anti-Platelet Substance.- Author Index.