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Fluorine in Heterocyclic Chemistry Volume 1: 5-Membered Heterocycles and Macrocycles

Editat de Valentine Nenajdenko
en Limba Engleză Paperback – 24 sep 2016
This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing  6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.
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Specificații

ISBN-13: 9783319379920
ISBN-10: 3319379925
Pagini: 690
Ilustrații: IX, 681 p. 1205 illus., 17 illus. in color.
Dimensiuni: 155 x 235 x 35 mm
Greutate: 0.96 kg
Ediția:Softcover reprint of the original 1st ed. 2014
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Cuprins

Tactical Applications of Fluorine in Drug Design and Development Kyle.- Chemistry of Fluorinated Pyrroles.- Chemistry of Fluorinated Indoles.- Fluorinated Indolizines.- Fluorinated Furans and Benzofurans.- Fluorinated Thiophenes and their Analogues.- Fluorinated Pyrazoles and Indazoles.- Fluorinated Imidazoles and Benzimidazoles.- Fluorinated Oxazoles, Thiazoles and Selenazoles.- Chemistry of Fluorinated Oxadiazoles and Thiadiazoles.- Fluorinated Triazoles and Tetrazoles.- 1,2-Bis (hetaryl) Perfluorocyclopentenes as Unique Thermally Irreversible Photochromes.- Synthesis and Structural Singularities.- Chemistry of α-Fluorinated Ethers- and Thioethers- Containing Heterocycles.- Fluorinated Porphyrins and Corroles: Synthesis, Electrochemistry, and Applications.- Fluorinated Phthalocyanines and their Analogues.

Notă biografică

Valentine G. Nenajdenko was born in 1967 in Ivanovo, Russia. He graduated from Moscow State University (Lomonosov) in 1991. He received his Ph.D. degree under the supervision of Professor E.S. Balenkova in 1994 researching the synthesis and application of unsaturated CF3 ketones. In 2000 he received Dr. of Chemistry degree involving the chemistry of sulfonium and iminium salts. In 2003 he became full Professor of Organic Chemistry at the Department of Chemistry of Moscow State University. His scientific interests include organic synthesis, asymmetric catalysis, the chemistry of sulfur and fluorine containing compounds, heterocyclic chemistry, multicomponent reactions. He have been a supervisor of 12 postgraduate studies. Prof. Nenajdenko is head of the Scientific Committee and Jury of International Mendeleev Chemistry Olympiad. He was the winner of the Academiae Europeae Award in 1997, the Russian President Award in 1996, the Prize for the best scientific work at the Department of Chemistry of Moscow State University in 2001 and 2007, the Shuvalov Award in 2001, the Russian President Award in 2004, Russian Science Support Foundation in 2005, Moscow State University Awards in 2006, 2007 and 2008.

Textul de pe ultima copertă

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing  6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Caracteristici

Has contributions from leading international fluorine chemists Provides a comprehensive listing of chemical, physical and physiochemical properties A treasure trove of fluorine data is clearly presented and classified Includes supplementary material: sn.pub/extras