The properties of proteins are determined not only by the sequence of amino-acid residues in the polypeptide chains, but also by the con­ figuration of the chains-the way in which the chains are coiled or folded. It is probable that denaturation, the loss of some of the specific properties of a native protein, may in many cases be the result simply of a change in configuration of the polypeptide chains, without any change whatever in the sequence of amino-acid residues. During the past few years great progress has been made in the attack on the determination of the sequence of amino-acid residues in the poly­ peptide chains of proteins, through the work of SANGER and his collabora­ tors (Io9, IIO) and of other investigators. There has also been significant progress in the attack on the problem of the configuration of polypeptide chains, largely through the application of the X-ray diffraction technique.