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Gene Therapy for Neurological Disorders and Brain Tumors de E. Antonio Chiocca

Gene Therapy for Neurological Disorders and Brain Tumors: Contemporary Neuroscience

Editat de E. Antonio Chiocca, Xandra O. Breakefield
en Limba Engleză Hardback – 23 oct 1997
Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

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Specificații

ISBN-13: 9780896035072
ISBN-10: 0896035077
Pagini: 458
Ilustrații: XI, 458 p.
Dimensiuni: 178 x 254 x 28 mm
Greutate: 1.2 kg
Ediția:1998
Editura: Humana Press Inc.
Colecția Humana
Seria Contemporary Neuroscience

Locul publicării:Totowa, NJ, United States

Public țintă

Research

Cuprins

1 Retrovirus Vectors and Regulatable Promoters.- 2 Characteristics of Adenovirus Vectors.- 3 HSV Recombinant Vectors: General Characteristics and Potential for Use in the Central Nervous System.- 4 HSV-1 Amplicon.- 5 AAV Vectors: General Characteristics and Potentialfor Use in the Central Nervous System.- 6 EBV Vectors: General Characteristics and Potential for Gene Therapy in the Central Nervous System.- 7 Lentiviral Vectors for Gene Delivery in the Central Nervous System.- 8 Promoters for Expression of Gene Products Within Neurons and Glia.- 9 Immune Response to Viral Vectors.- 10 Current Treatment Modalities for Brain Tumor: Surgery, Radiation, and Chemotherapy.- 11 Experimental and Clinical Gene Therapies for Brain Tumors.- 12 Tumor Suppressor Gene Therapy for Brain Tumors.- 13 Cytokine-Based Gene Therapy for Brain Tumors.- 14 Delivery of Therapeutic Genes to Brain and Intracerebral Tumors.- 15 Rat Brain Tumor Models and Statistical Evaluation of Survival Data in Experimental Neuro-Oncology.- 16 Gene Transfer for Adult CNS Regeneration and Aging.- 17 Gene Therapy for Parkinson’s Disease.- 18 Gene Therapy for Ischemic Stroke.- 19 Gene Therapy for the Lysomal Storage Diseases.- 20 Gene Therapy for Pain.- 21 Gene Therapy of Huntington’s Disease.

Recenzii

"a very interesting book. . .all 'gene therapy laboratories' and 'neuo-gene therapy laboratories' will be able to derive much intellectual nourishment and stimulation, practical tips, and predictions about the future from this truly challenging volume."-Human Genetics

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Drs. Chiocca and Breakefield bring together in Gene Therapy for Neurological Disorders and Brain Tumors many of the leading gene therapy researchers and clinicians to capture the breadth of the field-from basic vector technology to current and future clinical applications. The authoritative contributions provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorders, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea.

Gene Therapy for Neurological Disorders and Brain Tumors illuminates the rapidly developing applications of gene transfer technologies to the treatment of a wide range of neurological disorders and brain tumors. Readers will learn the current delivery methods for transgenes, will learn the characteristics of the transgene delivery vectors, and come to more fully understand gene therapies for both neuro-oncologic and neurologic disorders.