Genome Editing
Editat de Kursad Turksenen Limba Engleză Hardback – 18 aug 2016
This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions.
Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemicaland biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
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Specificații
ISBN-13: 9783319341460
ISBN-10: 3319341464
Pagini: 182
Ilustrații: IX, 166 p. 24 illus. in color.
Dimensiuni: 155 x 235 x 11 mm
Greutate: 0.43 kg
Ediția:1st ed. 2016
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
ISBN-10: 3319341464
Pagini: 182
Ilustrații: IX, 166 p. 24 illus. in color.
Dimensiuni: 155 x 235 x 11 mm
Greutate: 0.43 kg
Ediția:1st ed. 2016
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
Cuprins
Genome Editing with Targetable Nucleases.- CRISPR/Cas9 Approaches to Investigate
the Non-coding Genome.- At the Conflux of Human Genome Engineering and Induced
Pluripotency.- CRISPR/Cas9 and the Paradigm Shift in Mouse Genome Manipulation
Technologies.- Genome Editing Technology in CRISPR/Cas System: How to Increase
Knock-in Efficiency in Mouse Zygotes.- Developments in the Generation of Reporter
Stem Cells.- Current Status of Genome Editing in Cardiovascular Medicine.- Using
CRISPR-Cas9 Genome Editing to Enhance Cell Based Therapies for the Treatment of
Diabetes Mellitus.- Genome Editing in the Retina: a Case Study in CRISPR for a
Patient-Specific Autosomal Dominant Retinitis Pigmentosa Model.- Index.
Notă biografică
Kursad Turksen received his Ph.D. from the University of Toronto in Toronto, Canada in the area of osteoprogenitor biology and cell selection methodologies. He completed his postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, in Chicago, Illinois, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute in Ottawa, Canada [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen is currently Editor in Chief of the Springer journal Stem Cell Reviews and Reports in addition to serving as series editor for the Springer series Stem Cell Biology and Regenerative Medicine.
Textul de pe ultima copertă
This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions.
Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemicaland biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
Caracteristici
Presents the state of the science for CRISPR-Cas9 an increasingly hot field Will include chapters on current controversies and future directions Chapter authors are leaders in their fields and present expertise that is cutting-edge now and will evolve into key legacy research as this exciting and rapidly burgeoning field progresses Includes supplementary material: sn.pub/extras