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Genome Integrity: Facets and Perspectives: Genome Dynamics and Stability, cartea 1

Editat de Dirk-Henner Lankenau
en Limba Engleză Hardback – 7 noi 2006
Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.
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Specificații

ISBN-13: 9783540375289
ISBN-10: 3540375287
Pagini: 496
Ilustrații: XI, 496 p. With online files/update.
Dimensiuni: 155 x 235 x 33 mm
Greutate: 0.89 kg
Ediția:2007
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Genome Dynamics and Stability

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

Replication.- Chromosomal DNA Replication: On Replicases, Replisomes, and Bidirectional Replication Factories.- Progress Towards the Anatomy of the Eukaryotic DNA Replication Fork.- DNA Polymerases and Diseases.- Replicative Double-Strand Break Repair.- Facing Stalled Replication Forks: The Intricacies of Doing the Right Thing.- Germline Double-Strand Break Repair and Gene Targeting in Drosophila: A Trajectory System throughout Evolution.- Facets of Double-Strand Break Repair.- Structure and Function of Rad50/SMC Protein Complexes in Chromosome Biology.- Mechanisms of Non-Homologous DNA End Joining:Aspects of In Vitro Assays.- Role of p53 in Double-Strand Break Repair.- The Role of Chromatin Structure and Nuclear Architecture in the Cellular Response to DNA Double-Strand Breaks.- DNA Repair and Pleiotropic Interactions.- DNA Base Damage Recognition and Processing.- Inter- and Supramolecular Interactions of Protein Kinase CK2 and their Relevance for Genome Integrity.- Role of Human Topoisomerase I in DNA Repair and Apoptosis.- Genomic Instability in Fanconi Anaemia and Nijmegen Breakage Syndrome.- Radiation and other Genotoxic Stress.- Induction of DNA Repair Genes in Mammalian Cells in Response to Genotoxic Stress.- Pathways of DNA Double-Strand Break Repair in Mammalian Cells after Ionizing Radiation.- Genomic Instability:Signaling Pathways Orchestrating the Responsesto Ionizing Radiation and Cisplatin.- Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes.

Textul de pe ultima copertă

Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.

Caracteristici

First book to give a full overview on genome integrity in different species Spans from microorganisms to humans Addresses the connection between genome integrity and human disease Written by an international panel of experts