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Genomics of Pattern Recognition Receptors: Applications in Oncology and Cardiovascular Diseases de Anton G. Kutikhin

Genomics of Pattern Recognition Receptors: Applications in Oncology and Cardiovascular Diseases

Autor Anton G. Kutikhin, Arseniy E. Yuzhalin
en Limba Engleză Hardback – 9 sep 2013
This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
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Specificații

ISBN-13: 9783034806879
ISBN-10: 3034806876
Pagini: 250
Ilustrații: XI, 185 p.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.41 kg
Ediția:2013
Editura: Springer
Colecția Springer
Locul publicării:Basel, Switzerland

Public țintă

Research

Cuprins

The Biology of Toll-like Receptors and NOD-like Receptors: Toggles of Inflammation.- Pattern Recognition Receptors, Gene Polymorphisms, and Cancer: A Double-Edged Sword.- Structural Genomic Variation in Toll-Like Receptor 4 and Cancer.- Structural Genomic Variation in Other Toll-like Receptors and Cancer.- Structural Genomic Variation in Toll-Like Receptor Signaling Pathway and Cancer.- Structural Genomic Variation in Toll-like Receptor Pathway and Prostate Cancer.- Structural Genomic Variation in NOD-Like Receptors and Cancer.- Structural Genomic Variation in Pattern Recognition Receptors and Cardiovascular Diseases.- Hot Spots In the Field: Where Should We Go.

Recenzii

From the reviews:
“This book comprehensively covers the polymorphism of genes-encoding pattern recognition receptors (PRRs) … . The book is intended for immunologists, cancer researchers, cardiologists, epidemiologists, microbiologists, and geneticists, as well as PhD, graduate, and undergraduate students of biomedical faculties and their lecturers. This is a unique book that analyzes the field of PRR genomics and its practical applications. … This book will be quite useful for a very wide audience.” (Omer Iqbal, Doody’s Book Reviews, March, 2014)

Textul de pe ultima copertă

This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.

Caracteristici

Summarizes the field and indicates key directions
Explores and analyzes genomic variations
With numerous tables presenting the data systematically
Includes supplementary material: sn.pub/extras