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Nuclear Receptors: Methods and Experimental Protocols de Mostafa Z. Badr

Nuclear Receptors: Methods and Experimental Protocols: Methods in Molecular Biology, cartea 1966

Editat de Mostafa Z. Badr
en Limba Engleză Hardback – mai 2019
This volume presents valuable techniques for studying the class of ligand-activated transcription factors known as nuclear receptors. After a brief overview of the history of the field, chapters cover methods to detect the receptors and their mRNAs in various tissues, protocols to characterize nuclear receptor modulators and activities, their signaling and roles in certain pathogenesis, molecular modeling of nuclear receptor-ligand interactions, as well as the utility of informatics in the field of nuclear receptors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and cutting-edge, Nuclear Receptors: Methods and Experimental Protocols seeks to aid researchers working toward furthering ourunderstanding of these vital receptors and their role in numerous pathological conditions.
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Specificații

ISBN-13: 9781493991945
ISBN-10: 1493991949
Pagini: 342
Ilustrații: XII, 314 p. 72 illus., 57 illus. in color.
Dimensiuni: 178 x 254 mm
Greutate: 0.73 kg
Ediția:1st ed. 2019
Editura: Springer
Colecția Humana
Seria Methods in Molecular Biology

Locul publicării:New York, NY, United States

Cuprins

Nuclear Receptors: A Historical Perspective.- An Optimized Immunoblotting Protocol for Accurate Detection of Endogenous PGC-1α Isoforms in Various Rodent Tissues.- Sub-Cellular Localization of NR4A2 Orphan Nuclear Receptor Expression in Human and Mouse Synovial Joint Tissue.- In Vivo Quantitation of Estrogen Receptor b Subtype Expression in Ovarian Surface Epithelium Using Immunofluorescence Profiling and Confocal Microscopy.- In Vivo ChIP-Seq of Nuclear Receptors: A Rough Guide to Transform Frozen Tissues into High Confidence Genome-Wide Binding Profiles.- High-Content Analysis of Constitutive Androstane Receptor Nuclear Translocation.- Antibody Validation Strategy for Nuclear Receptors.- Immunofluorescence Labeling of Nuclear Receptor Expression in Formalin-Fixed Paraffin-Embedded Tissue.- Detection of ADP-Ribosylation of the Androgen Receptor Using the Recombinant Macrodomain AF1521 from Archaeoglobus fulgidus.- Reconstitution of the Steroid ReceptorHeterocomplex.- High-Throughput Imaging of PPIX Using Confocal Microscopy.- PGC-1α Overexpression via Local In Vivo Transfection in Mouse Skeletal Muscle.- A Reverse Transfection Method for Screening of Nuclear Receptor Activators.- Hybrid Reporter Gene Assays: Versatile In Vitro Tools to Characterize Nuclear Receptor Modulators.- Analysis of the Transcriptional Activity of Retinoic Acid-Related Orphan Receptors (RORs) and Inhibition by Inverse Agonists.- Examining the Role of Nuclear Receptors during In Vivo Chemical-Mediated Breast Tumorigenesis.- Analysis of IL-4/STAT6 Signaling in Macrophages.- Isolation and Characterization of Adipose Tissue Macrophages.- Assessing Mitochondrial Bioenergetics in Isolated Mitochondria from Mouse Heart Tissues Using Oroboros 2k-Oxygraph.- Generation of Skeletal Myocytes from Embryonic Stem Cells through Nuclear Receptor Signaling.- Obtaining Crystals of PPARγ Ligand Binding Domain Bound to Small Molecules.- Molecular Modeling Approach to Study the PPARγ-Ligand Interactions.- High Dimensional Data Approaches to Understanding Nuclear Hormone Receptor Signaling.

Textul de pe ultima copertă

This volume presents valuable techniques for studying the class of ligand-activated transcription factors known as nuclear receptors. After a brief overview of the history of the field, chapters cover methods to detect the receptors and their mRNAs in various tissues, protocols to characterize nuclear receptor modulators and activities, their signaling and roles in certain pathogenesis, molecular modeling of nuclear receptor-ligand interactions, as well as the utility of informatics in the field of nuclear receptors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and cutting-edge, Nuclear Receptors: Methods and Experimental Protocols seeks to aid researchers working toward furthering our understanding of these vital receptors and their role in numerous pathological conditions.

Caracteristici

Includes cutting-edge techniques Provides step-by-step detail essential for reproducible results Contains key implementation advice from the experts

Notă biografică

Dr. Mostafa Z. Badr is a Professor Emeritus at the University of Missouri-Kansas City, USA. Dr. Badr obtained his Bachelor degree in Pharmacy and a Master’s degree in Organic Chemistry from the Faculty of Pharmacy, Cairo University, Egypt. Dr. Badr subsequently obtained a Ph.D. Degree in Pharmacology and Toxicology from the University of Louisville, after which he received postdoctoral training in Toxicology at the University of North Carolina-Chapel Hill. In 1987 Dr. Badr accepted the position of Assistant Professor at the University of Missouri-Kansas City School of Pharmacy, where he retired as Professor in 2015.
 
Dr. Badr has authored and co-authored over 70 publications in peer-reviewed journals, and has published three previous books with Springer Nature. Dr. Badr founded the journal of PPAR Research and served as its Editor-in-Chief from 2005-2011, and the journal of Nuclear Receptor Research and served as its Editor-in-Chief from 2013 until 2019.  
Mostafa Badr, Ph.D.
Kansas City, MO, USA
November 2020.