IL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity: Progress in Inflammation Research
Editat de Valérie Quesniaux, Bernhard Ryffel, Franco Di Padovaen Limba Engleză Hardback – 14 dec 2012
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Specificații
ISBN-13: 9783034805216
ISBN-10: 3034805217
Pagini: 364
Ilustrații: X, 354 p.
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.66 kg
Ediția:2nd ed. 2013
Editura: Springer
Colecția Springer
Seria Progress in Inflammation Research
Locul publicării:Basel, Switzerland
ISBN-10: 3034805217
Pagini: 364
Ilustrații: X, 354 p.
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.66 kg
Ediția:2nd ed. 2013
Editura: Springer
Colecția Springer
Seria Progress in Inflammation Research
Locul publicării:Basel, Switzerland
Public țintă
ResearchCuprins
IL-17A family, receptors, proinflammatory effects and production.- IL-22 and IL-17 overview.- IL-17R family: Structure, signal transduction and function.- Contribution of IL-22 to Th17 responses: repairing and protecting peripheral tissues.- Central role of Th-17 cells in adaptive immune responses.- Regulatory T cells vs Th17: Differentiation of Th17 versus Treg are they mutually exclusive Other sources of IL-17: iNKT cells.- Retinoic acid in mucosal immune regulation.- Critical role of IL-17 in experimental arthritis.- Dual role IL-17A, F and IL-22 in allergic asthma.- Inflammasome - IL-1 - IL-17 response in lung inflammation.- The role of Il-17 in exp autoimmune mycocarditis.- Th17 cells in transplantation: actors or innocent bystanders.- Is IL-17 required to control of tuberculosis IL-17 and mucosal host defense. Role of IL-17 and IL-17 family cytokines on tumor development.- IL-17 and TH17 cells in rheumatoid arthritis and other inflammatory conditions.- Targeting Th17 Cells for therapy of multiple sclerosis.- Involvement of interleukin-17 cytokines in human asthma.- IL-17 and/or IL-22 as potential target(s) for Crohn’s disease.- Role of IL-23, IL-17 and IL-22 in psoriasis.- Contribution of IL-22 to experimental skin inflammation.- Genetic mouse models to investigate IL-17 responses.- IL-17A as a therapeutic target for autoimmune diseases.
Textul de pe ultima copertă
The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
Caracteristici
Comprehensive review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells Completely revised 2nd edition, including additional chapters on the IL-17 receptor family and signaling, or on IL-22 and innate lymphoid cells Latest clinical progress in neutralizing IL-17 antibodies Includes supplementary material: sn.pub/extras