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Bone Morphogenetic Proteins: Regeneration of Bone and Beyond: Progress in Inflammation Research

Editat de Slobodan Vukicevic, Kuber T. Sampath
en Limba Engleză Hardback – 20 aug 2004
Since the discovery of the bone morphogenetic proteins (BMPs) more than 15 years ago, there has been an unpredicted explosion of both basic scientific discoveries and clinical reports on their use from institutions all over the world. The potent effica­ cy of BMPs in almost all crucial developmental events as well as during regenera­ tion of various organs such as bone, kidney, brain, liver, heart etc. , has positioned BMPs at the center of scientific interest. Many of these aspects are covered in this new PIR volume. Their role in development, biology, signal transduction, kidney regeneration, eNS functions, craniofacial skeleton reconstruction, joint and carti­ lage repair, long bone non-unions and acute fractures, and spinal fusion is reviewed by experts in the field. For the first time, the role of BMPs in carcinogenesis has been reviewed to provide a rationale for applying their biology in patients with bone tumors. The optimism resulting from safe and successful treatment with BMPs for various skeletal malformations of more than 10,000 patients worldwide has opened new avenues for exploring other indications for their use. The next big challenge for bringing BMPs to the benefit ofmankind is in regenerating articular cartilage defects and rescuing patients with acute and chronic renal failure. The volume editors thank all authors for the rapid preparation of their chapters in order that the book remains up-to-date for readers with specific interest in the field of regenerative medicine. The important contribution of Mrs. Morana and Mr.
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Specificații

ISBN-13: 9783764371395
ISBN-10: 3764371390
Pagini: 312
Ilustrații: XI, 312 p.
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.64 kg
Ediția:2004
Editura: Birkhäuser Basel
Colecția Birkhäuser
Seria Progress in Inflammation Research

Locul publicării:Basel, Switzerland

Public țintă

Research

Cuprins

Bone morphogenetic proteins and their role in regenerative medicine.- Bone morphogenetic protein receptors and their nuclear effectors in bone formation.- Biology of bone morphogenetic proteins.- Bone morphogenetic proteins in development.- Bone morphogenetic proteins in articular cartilage repair.- Craniofacial reconstruction with bone morphogenetic proteins.- Clinical experience of osteogenic protein-1 (OP-1) in the repair of bone defects and fractures of long bones.- Development of the first commercially available recombinant human bone morphogenetic protein (rhBMP-2) as an autograft replacement for spinal fusion and ongoing R & D direction.- Bone morphogenetic proteins and the synovial joints.- The role of bone morphogenetic proteins in developing and adult kidney.- Bone morphogenetic proteins in the nervous system.- Bone morphogenetic proteins and cancer.- Bone healing: Bone morphogenetic proteins and beyond.

Caracteristici

Updated version of the first PIR-volume on BMPs by S. Vukicevic/K.T. Sampath, Bone Morphogenetic Proteins - From Laboratory to Clinical Practice (2002), with several new contributions A topical book written by experts in the field

Textul de pe ultima copertă

Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.
In this volume, we summarize the advances made on the local and systemic use of BMPs including chapters covering the regulation of BMP-signalling pathways, biological actions of BMPs in bone, cartilage and teeth, as well as clinical applications and potential systemic use of BMPs for tissues beyond bone.
This volume is of interest to researchers from immunology, cell biology, biochemistry, and clinicians from orthopedics and dentistry, as well as to research managers from biotech and pharmaceutical companies.