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Bone Morphogenetic Proteins: From Laboratory to Clinical Practice de Slobodan Vukicevic

Bone Morphogenetic Proteins: From Laboratory to Clinical Practice: Progress in Inflammation Research

Editat de Slobodan Vukicevic, Kuber T. Sampath
en Limba Engleză Paperback – 23 oct 2012
From the basic science to potential and approved clinical applications the most recent data in the rapidly growing field of bone morphogenetic proteins (BMPs) are summarized in this topical volume. Distinguished scientists present reviews on a range of scientific topics, including biochemistry, biology, molecular biology and preclinical animal studies on spinal fusion, cartilage repair, craniofacial and dental reconstruction using BMPs, as well as approved clinical applications in human bone non-unions.
This book provides a resource not only for experts in the field, but also for undergraduate students, newcomers and clinicians worldwide, given that the use of BMPs in orthopedic reconstruction has been already approved in Europe, Australia, Canada and the USA.
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Specificații

ISBN-13: 9783034894463
ISBN-10: 3034894465
Pagini: 344
Ilustrații: XII, 328 p.
Dimensiuni: 155 x 235 x 22 mm
Greutate: 0.48 kg
Ediția:Softcover reprint of the original 1st ed. 2002
Editura: Birkhäuser Basel
Colecția Birkhäuser
Seria Progress in Inflammation Research

Locul publicării:Basel, Switzerland

Public țintă

Research

Cuprins

Biochemistry of bone morphogenetic proteins.- Prostate-derived factor and growth and differentiation factor-8:newly discovered members of the TGF-? superfamily.- Bone morphogenetic protein receptors and their nuclear effectorsin bone formation.- Deciphering the binding code of BMP-receptor interaction.- Biology of bone morphogenetic proteins.- Preclinical models of recombinant BMP induced healingof orthopedic defects.- Osteogenic protein-1 (OP-1, BMP-7) for stimulation of healingof closed fractures: evidence based medicine and pre-clinical experience.- Maxillofacial reconstruction.- Bone morphogenetic proteins in periodontal regeneration.- Osteogenic protein-1 (OP-1) in the repair of bone defects and fracturesof long bones: clinical experience.- Evaluation of OP-1 in a rabbit model of lumbar fusions.- Bone morphogenetic proteins and the synovial joints.- BMPs in articular cartilage repair.- The role of bone morphogenetic proteins in kidney development and repair.- Effects of bone morphogenetic proteins on neural tissues.

Caracteristici

Provides a good overview on the role of BMPs as regulators in Systems Biology? Complements the first three volumes on BMPs in the series (BMPs-from laboratory to clinical practice; BMPs-regeneration of bone and beyond; BMPs-from local to systemic therapeutics) Adresses their role in orthopaedic and dental medicine as well as in development, cancer, PAH, chronic kidney diseases and others

Textul de pe ultima copertă

Tissue engineering is gaining interest as it is applied for regeneration of organs to attain their lost function. Although resorbable scaffolds and progenitor cell types are required principles to engineer a functional tissue locally, the inductive signal is a prerequisite to trigger the growth and differentiation of responding cells in space and time. Bone morphogenetic proteins (BMPs), also called growth and differentiation factors (GDFs), originally identified from bone have been successfully used to regenerate the bone in humans. Most recent preclinical data suggests that BMPs have a potential to provide protection against inflammation and fibrosis in acute and chronic injury of parenchymal tissues when applied systemically to sustain the function of kidney and liver. The application of BMPs from a local to systemic utility is a rapidly growing field, gaining interest among researchers and biotech entrepreneurs.
In this volume, we summarize the advances made on the local and systemic use of BMPs including chapters covering the regulation of BMP-signalling pathways, biological actions of BMPs in bone, cartilage and teeth, as well as clinical applications and potential systemic use of BMPs for tissues beyond bone.
This volume is of interest to researchers from immunology, cell biology, biochemistry, and clinicians from orthopedics and dentistry, as well as to research managers from biotech and pharmaceutical companies.