In this issue of Orthopedic Clinics, guest editors from the esteemed Campbell Clinic bring their considerable expertise to the topic of Infections. Eleven top experts discuss key concepts relating to infections to guide effective decision making. Early diagnosis and treatment are key to success, and in order to address an infection, the medical care team needs to address four fundamental questions: where is it, what is it, how severe is it, and how to treat it. The articles outlined in this issue will help physicians better understand common pathogens, identify signs of infection, and ultimately answer these fundamental questions in order to improve patient outcomes.