In this issue of Orthopedic Clinics, a team of eleven guest editors from the Campbell Clinic bring their considerable expertise to the topic of Managing Comorbidities. Top experts in the field cover key topics such as preventing the impact of hyperglycemia and diabetes on patients undergoing total joint arthroplasty; managing the patient with peripheral artery disease before TKA surgery; how to best utilize pediatric subspecialists; management of gout in the upper extremity; and more.