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Long Non-coding RNAs in Human Disease de Kevin V. Morris

Long Non-coding RNAs in Human Disease: Current Topics in Microbiology and Immunology, cartea 394

Editat de Kevin V. Morris
en Limba Engleză Paperback – 22 apr 2018
Thisvolume focuses on the roles of long non-coding RNAs (lncRNAs) in contextsranging from human cancers to cardiovascular disease and ageing. The role oflncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, pastretroelements integrated within the human genome, as well as the role thesepseudogene-derived lncRNAs play in cancer development are discussed in detail. Further,the book examines the function of lncRNAs in diseases such as diabetes, in smoothmuscle formation, and in the modulation of nuclear receptors, as well as inconnection with perspectiveson the development ofpersonalized therapeutics. It offers an appealing and insightful resource forscientists and clinicians alike.
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Specificații

ISBN-13: 9783319795515
ISBN-10: 3319795511
Ilustrații: VIII, 262 p.
Dimensiuni: 155 x 235 mm
Greutate: 0.39 kg
Ediția:2016
Editura: Springer International Publishing
Colecția Springer
Seria Current Topics in Microbiology and Immunology

Locul publicării:Cham, Switzerland

Cuprins

Understandingthe Complex Circuitry of lncRNAs at the X-inactivation Center and itsImplications in Disease Conditions.- Long Non-coding RNA ANRIL and Polycomb inHuman Cancers and Cardiovascular Disease.- Form and function of exosomeassociated long non-coding RNAs in cancer.- Long Non-coding RNAs in Lung Cancer.-Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease.- Functionallong non-coding RNAs in vascular smooth muscle cells.- Long Non-coding RNAs asTargets and Regulators of Nuclear Hormone Receptors.- Non-codingtranscriptional landscape in human aging.- LncRNAs in stress response.- ExpressionSpecificity of Disease-Associated lncRNAs: towards Personalized Medicine.  

Notă biografică

Kevin Morris is an Associate Professor at the Department of Molecular and Experimental Medicine, The Scripps Research Institute in La Jolla, CA, USA. The responsible series editor is Peter K. Vogt, The Scripps Research Institute in La Jolla, CA, USA.

Textul de pe ultima copertă

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Caracteristici

Summarizes the tremendous progress made within the last decade in understanding the roles of lncRNA in Bridges the divide betweeninferring lncRNA mechanisms and targeting lncRNAs by means of rationaltherapeutics Stresses the vital role oflncRNA disease mechanisms for a necessary and profound reassessment ofGenome-Wide Association studies in the new era of personalized medicine Includes supplementary material: sn.pub/extras