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Medullary Thyroid Carcinoma de Friedhelm Raue

Medullary Thyroid Carcinoma: Recent Results in Cancer Research, cartea 125

Editat de Friedhelm Raue
en Limba Engleză Paperback – 30 dec 2011
Medullary Thyroid Carcinoma is a rare thyroid tumororiginating from neural crest cells, the C-cell that impliesseveral special features, secretion of differentneuroendocrine markers, association with other endocrinetumors and familial appearance. The familial variant ofmedullary thyroid carcinoma allows an early detection bybiochemical and genetic testing. At that stage acceptablesurgical treatment will cure the patient. The sporadic formof medullary thyroid carcinoma will be diagnosed in aprogressive stage, but adequate surgical procedure can curethese patients too. Long term survival depends on stage,age, sex, and variant of the disease and seems to be as goodas in other differentiated thyroid cancers.
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Specificații

ISBN-13: 9783642847516
ISBN-10: 364284751X
Pagini: 232
Ilustrații: X, 216 p. 27 illus.
Dimensiuni: 155 x 235 x 12 mm
Greutate: 0.33 kg
Ediția:Softcover reprint of the original 1st ed. 1992
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Recent Results in Cancer Research

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

Biological Aspects of Medullary Thyroid Carcinoma.- Regulation of Calcitonin Secretion and Calcitonin Gene Expression.- Pathology of Sporadic and Hereditary Medullary Thyroid Carcinoma.- Epidemiology of Medullary Thyroid Carcinoma.- Clinical and Diagnostic Aspects of Medullary Thyroid Carcinoma.- Tumor Markers for the Medullary Thyroid Carcinoma.- Sporadic Medullary Thyroid Carcinoma: Clinical Features and Diagnosis.- Screening for MEN 2 with Biochemical and Genetic Markers.- Imaging Methods for Medullary Thyroid Cancer.- Therapeutic Procedure in Medullary Thyroid Carcinoma.- Surgical Strategies and Methods for the Treatment of Metastasizing Medullary Thyroid Carcinoma.- Surgical Management of MEN 2.- Postsurgical Follow-Up and Management.

Textul de pe ultima copertă

​This book offers a comprehensive overview of medullary thyroid carcinoma, both in the more common sporadic form and in the familial form, multiple endocrine neoplasia (MEN) types 2A and 2B. The coverage includes, but is not limited to, molecular biology and genetics, pathology, clinical presentation, imaging techniques, surgical treatment, and follow-up. The role of calcitonin as a highly sensitive and specific tumor marker for the screening, diagnosis, and follow-up of MTC and metastatic disease is described, and the significance of other tumor markers is also considered. With regard to treatment, the use of thyroidectomy is fully discussed, including in children carrying the mutations in the RET proto-oncogene considered causative for MEN 2. Additionally, the value of tyrosine kinase inhibitors as the most effective treatment modality in patients with a large tumor burden or rapid tumor growth, or both, is explained. Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.

Caracteristici

Provides a comprehensive overview on the different forms of medullary thyroid carcinoma and their management Describes the role of calcitonin and other tumor markers Explains the use of thyroidectomy and tyrosine kinase inhibitors Includes supplementary material: sn.pub/extras