Metal-Responsive Base Pair Switching of Ligand-type Uracil Nucleobases: Springer Theses
Autor Keita Morien Limba Engleză Hardback – 4 feb 2024
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Specificații
ISBN-13: 9789819993994
ISBN-10: 9819993997
Pagini: 125
Ilustrații: XVII, 125 p. 111 illus., 101 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.39 kg
Ediția:1st ed. 2024
Editura: Springer Nature Singapore
Colecția Springer
Seria Springer Theses
Locul publicării:Singapore, Singapore
ISBN-10: 9819993997
Pagini: 125
Ilustrații: XVII, 125 p. 111 illus., 101 illus. in color.
Dimensiuni: 155 x 235 mm
Greutate: 0.39 kg
Ediția:1st ed. 2024
Editura: Springer Nature Singapore
Colecția Springer
Seria Springer Theses
Locul publicării:Singapore, Singapore
Cuprins
1. General introduction.- 2. Metal-responsive DNA strand displacement reactions driven by base pair switching of 5-hydroxyuracil nucleobases.- 3. Metal-dependent base pair switching of N,N,-dicarboxymethyl-5-aminouracil nucleosides.- 4. Metal-responsive DNA tweezers driven by base pair switching of 5-hydroxyuracil nucleobases.- 5. Conclusion and perspectives.
Notă biografică
Keita Mori received his B.Sc., M.Sc., and Ph.D. in chemistry from the School of Science, The University of Tokyo in 2018, 2020, and 2023, respectively, under supervision of Prof. Mitsuhiko Shionoya. In 2022, he joined Prof. Hanadi Sleiman's group at McGill University as a visiting researcher. He is now a JSPS postdoctoral fellow at Tokyo University of Agriculture and Technology (Prof. Takahiro Muraoka's group). His research interests focus on dynamic control of biomolecular structures and functions using synthetic molecules.
Textul de pe ultima copertă
In this thesis, the author proposes "metal-responsive base pair switching" of ligand-modified nucleobases as a novel tool for stimuli-responsive control of DNA assemblies. It is written to demonstrate broad applicability of the base pair switching in dynamic DNA nanotechnology and inspire researchers to use this technique. Based on specific interactions between ligand-type nucleobases and target metal ions, in this volume, DNA hybridization was dynamically controlled through strand displacement reactions. The base pair switching was further applied to develop metal-dependent DNA molecular machines. This novel strategy for stimuli-responsive regulation of DNA assemblies will greatly expand the scope of dynamic DNA nanotechnology. This volume uniquely features importance of elaborate molecular design based on chemistry for imparting stimuli responsiveness to DNA assemblies.
Caracteristici
Is nominated by The University of Tokyo as an outstanding Ph.D. thesis Demonstrates novel methodology for dynamic control of DNA assemblies Expands the scope of dynamic DNA nanotechnology