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MicroRNAs: Key Regulators of Oncogenesis de Sadegh Babashah

MicroRNAs: Key Regulators of Oncogenesis

Editat de Sadegh Babashah
en Limba Engleză Hardback – 7 mar 2014
Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.
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Specificații

ISBN-13: 9783319037240
ISBN-10: 3319037242
Pagini: 433
Ilustrații: XXVI, 433 p. 26 illus., 21 illus. in color.
Dimensiuni: 155 x 235 x 25 mm
Greutate: 1.02 kg
Ediția:2014
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Public țintă

Research

Cuprins

Preface.- Part I MicroRNAs: biology and implications in cancer.- MicroRNAs and cancer: an overview.- Epigenetics and microRNA in cancer.- MicroRNA, diet and cancer chemoprevention.- MicroRNAs and energy metabolism in cancer cells.- MicroRNAs and solid tumors.- MicroRNAs and blood cancers.- MicroRNAs and oncogenic human viruses.- MicroRNAs linking cancer and inflammation: focus on liver cancer.- MicroRNAs and regulatory pathways in tumorigenesis.- MicroRNA-modulated apoptotic and autophagic signaling networks in cancer.- MicroRNAs and cancer drug resistance and drug sensitivity.- The biological roles of microRNAs in cancer stem cells.- Part II MicroRNAs and their clinical implications.- MicroRNAs and clinical implications in cancer.- MicroRNA expression profiling and its clinical impact in breast cancer.- MicroRNAs and their clinical impact on resistance to anticancer treatment.- Nanocarriers and microRNA-based scenarios for cancer therapy.- Challenges and strategies for pulmonary delivery of microRNA-based therapeutics.- Abbreviations.- Index.

Textul de pe ultima copertă

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs play a momentous role in oncogenesis via regulating cell proliferation and apoptosis as oncogenes or tumour suppressors. Expression signatures of miRNAs offer exciting opportunities for crafting cutting edge strategies in the diagnosis, prognosis, and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in the tortuous route of oncogenesis, the promise represented by using these small RNAs as therapeutic targets presents new perspectives to the landscape of cancer therapy by either inhibiting or augmenting their activity. This book devotes efforts to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of miRNAs found to be associated with cancer pathogenesis and possible mechanisms underlying the substantial roles played by miRNAs in cancer development and progression. Also, it intends to pave the way for readers to gain novel insights into using miRNAs as cancer biomarkers and therapeutic platforms.

Caracteristici

The contents of this book was scrupulously designed and explicitly written Ranging from the fundamental concepts to clinical applications, this book is composed of seventeen chapters organized in two parts The first part is devoted to delving deep into the importance of miRNAs in cancer biology The Second part of the book highlights the clinical implications of miRNAs in cancer Includes supplementary material: sn.pub/extras