Mitochondria: Basic Life Sciences
Autor Alexander Tzagoloffen Limba Engleză Paperback – 15 apr 2013
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Specificații
ISBN-13: 9781461332961
ISBN-10: 1461332966
Pagini: 360
Ilustrații: XV, 342 p. 46 illus.
Dimensiuni: 178 x 254 x 19 mm
Greutate: 0.62 kg
Ediția:Softcover reprint of the original 1st ed. 1982
Editura: Springer Us
Colecția Springer
Seria Basic Life Sciences
Locul publicării:New York, NY, United States
ISBN-10: 1461332966
Pagini: 360
Ilustrații: XV, 342 p. 46 illus.
Dimensiuni: 178 x 254 x 19 mm
Greutate: 0.62 kg
Ediția:Softcover reprint of the original 1st ed. 1982
Editura: Springer Us
Colecția Springer
Seria Basic Life Sciences
Locul publicării:New York, NY, United States
Public țintă
ResearchCuprins
1 Evolution of Mitochondrial Studies.- I. Early Cytological Studies (1850–1900).- II. Early Studies of Biological Oxidation Reactions (1900–1940).- III. Identification of Mitochondria as Centers of Energy Metabolism (1940–1950).- IV. Gross and Fine Structure of Mitochondria.- V. Electron Transfer.- VI. Oxidative Phosphorylation.- VII. Biogenesis and Genetics of Mitochondria.- Selected Readings.- 2 Mitochondrial Structure and Compartmentalization.- I. Gross Morphology of Mitochondria.- II. Subfractionation of Mitochondria.- III. Distribution of Mitochondrial Enzymes.- IV. Composition of the Inner and Outer Membranes.- V. Current Views on the Structure of Biological Membranes.- VI. Fine Structure of Mitochondrial Membranes.- Selected Readings.- 3 Oxidative Pathways of Mitochondria.- I. Conversion of Pyruvic Acid to Acetyl-CoA.- II. ?-Oxidation of Fatty Acids.- III. Utilization of Ketone Bodies.- IV. Metabolism of Amino Acids.- V. Tricarboxylic Acid Cycle.- VI. Yield of ATP from the Aerobic Oxidation of Glucose.- Selected Readings.- 4 The Electron Transfer Chain.- I. Carriers of the Electron Transfer Chain.- II. Redox Potentials of the Electron Transfer Chain Carriers.- III. Sequence of Electron Transfer Carriers Based on their Rates of Oxidation and Reduction.- IV. Inhibitors of Electron Transfer.- V. Properties of the Respiratory Complexes.- VI. Stoichiometry of the Electron Transfer Carriers.- VII. Other Respiratory Chain-Linked Dehydrogenases.- Selected Readings.- 5 Cytochrome Oxidase: Model of a Membrane Enzyme.- I. Purification and Assay of Cytochrome Oxidase.- II. Structure of Cytochrome Oxidase.- III. Formation of Cytochrome Oxidase Membranes.- IV. Shape of Cytochrome Oxidase.- V. Phospholipid Activation of Enzymatic Activity.- VI. Mechanism of Catalysis.-Selected Readings.- 6 Oxidative Phosphorylation.- I. The Concept of Coupling.- II. Uncouplers and Inhibitors of Oxidative Phosphorylation.- III. Efficiency of Phosphorylation.- IV. Phosphorylation Sites.- V. Evidence for the Existence of a Nonphosphorylated Intermediate.- VI. Partial Reactions of Oxidative Phosphorylation.- VII. Role of Structure in Oxidative Phosphorylation.- VIII. Current Theories of the Coupling Mechanism.- Selected Readings.- 7 The Mitochondrial Adenosine Triphosphatase.- I. Purification and Properties of the ATPase Complex.- II. Functional Components of the ATPase Complex.- III. Ultrastructure of the ATPase.- IV. Catalytic Mechanism of the ATPase.- V. Coupling Factor Activity of ATPase Components.- Selected Readings.- 8 Resolution and Reconstitution of Electron Transport and Oxidative Phosphorylation.- I. Electron Transport Chain.- II. Reconstitution of the Electron Transfer Complexes.- III. Resolution of Oxidative Phosphorylation in Submitochondrial Particles.- IV. Reconstitution of a Coupled ATPase Membrane.- V. Reconstitution of Coupled Electron Transport Membranes.- VI. Reconstitution of Oxidative Phosphorylation.- Selected Readings.- 9 Mitochondrial Transport Systems.- I. Some General Considerations of How Molecules Cross Biological Membranes.- II. Methodology for Studying Mitochondrial Transport.- III. Passive Diffusion of Gases and Water.- IV. Mechanisms of Substrate Transport in Mitochondria.- V. Transport of Specific Substrates.- VI. Substrate Transport and Coordination of Mitochondrial and Cytoplasmic Metabolism.- VII. Metal Transport.- Selected Readings.- 10 Mitochondrial Biogenesis.- I. Mitochondrial Continuity.- II. Components of the Mitochondrial Translation Machinery.- III. Mitochondrial Protein Synthesis.- IV. Phospholipid Biosynthesis.- V. Nuclear Gene Products.- VI. Transport of Proteins into Mitochondria.- VII. Biosynthesis of Inner Membrane Enzymes.- Selected Readings.- 11 Mitochondrial Genetics.- I. Mitochondrial DNA.- II. Life Cycle of Saccharomyces cerevisiae.- III. Genetic Criteria for Distinguishing Nuclear and Mitochondrial Mutations.- IV. Mitochondrial Genes and Mutants.- V. Genetic Methods for Mapping Mitochondrial Mutations.- VI. Physical Mapping of Mitochondrial Genes.- VII. Sequencing of Mitochondrial DNA.- VIII. Transcription of mtDNA and Processing of RNA.- IX. Evolution of Mitochondria.- Selected Readings.