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Multiparticulate Oral Drug Delivery de Isaac Ghebre-Selassie

Multiparticulate Oral Drug Delivery

Editat de Isaac Ghebre-Selassie
en Limba Engleză Paperback – 19 sep 2019
This definitive reference explores the various aspects of multiparticulate dosage form development-assessing the in vivo behavior and performance of multiparticulates as well as comparing their market position to other dosage forms.
Discussing-for the first time in a comprehensive manner-alternative pelletization techniques such as balling (spherical agglomeration), spray congealing, and cryopelletization, Multiparticulate Oral Drug Delivery
  • describes formulation and processing variables that affect the formation, integrity, and performance of coatings derived from molten materials and polymeric solutions and dispersions
  • analyzes the biopharmaceutical aspects and in vivo performance of multiparticulate drug delivery systems
  • details the idiosyncrasies of the manufacturing process of hard-shell gelatin capsules
  • explains the different kinds of packaging materials and machinery and the importance of packaging during the development phase and beyond
  • previews the marketing considerations of multiparticulate systems in the years to come
  • presents practical solutions to problems encountered in the area of film-coating processes
  • and more!
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    Specificații

    ISBN-13: 9780367402044
    ISBN-10: 0367402041
    Pagini: 496
    Dimensiuni: 152 x 229 x 38 mm
    Greutate: 0.45 kg
    Ediția:1
    Editura: CRC Press
    Colecția CRC Press

    Public țintă

    Academic and Professional Practice & Development

    Cuprins

    Manufacture of Core Pellets by Balling
    Preparation of Micropellets by Spray Congealing
    Cryopelletization
    Coating of Multiparticulates Using Polymeric Solutions: Formulation and Process Considerations
    Coating of Multiparticulates Using Polymeric Dispersions: Formulation and Process Considerations
    Coating of Multiparticulates Using Molten Materials: Formulation and Process Considerations,
    Suspensions and Dispersible Dosage Forms of Multiparticulates, Roland Bodmeier and Ornlaksana Paeratakul
    Multiparticulate Encapsulation Equipment and Process
    Compaction of Multiparticulate Oral Dosage Forms
    Key Factors in the Development of Modified-Release Pellets
    Mechanisms of Release from Coated Pellets
    Biopharmaceutical Aspects of Multiparticulates
    In Vivo Behavior of Multiparticulate Versus Single-Unit Dose Formulations
    Capsule Shell Composition and Manufacturing
    Packaging of Multiparticulate Dosage Forms: Materials and Equipment
    Marketing Considerations

    Descriere

    This definitive reference explores the various aspects of multiparticulate dosage form development—assessing the in vivo behavior and performance of multiparticulates as well as comparing their market position to other dosage forms. It discusses alternative pelletization techniques such as balling (spherical agglomeration), spray congealing, and cryopelletization. The book also covers formulation and processing variables that affect the formation, integrity, and performance of coatings derived from molten materials and polymeric solutions and dispersions and details the idiosyncrasies of the manufacturing process of hard-shell gelatin capsules.