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National Institute of Allergy and Infectious Diseases, NIH: Volume 3: Intramural Research de Vassil St. Georgiev

National Institute of Allergy and Infectious Diseases, NIH: Volume 3: Intramural Research: Infectious Disease

Editat de Vassil St. Georgiev
en Limba Engleză Paperback – 6 noi 2012
National Institute of Allergy and Infectious Diseases, NIH: Volume III: Intramural Research contains a broad overview of the research activity of the NIAID intramural scientists working in the Division of Intramural Research (DIR) and the Vaccine Research Center (VRC), both in the Bethesda campus, and the Rocky Mountains Research Laboratories. Each of these laboratories employs scientists internationally recognized as leaders in their fields of biomedical research.
This volume focuses on individual research contributions by internationally known scientists doing research in the NIAID laboratories.
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Specificații

ISBN-13: 9781617797064
ISBN-10: 1617797065
Pagini: 472
Ilustrații: XX, 452 p.
Dimensiuni: 210 x 279 x 25 mm
Greutate: 1.05 kg
Ediția:2010
Editura: Humana Press Inc.
Colecția Humana
Seria Infectious Disease

Locul publicării:Totowa, NJ, United States

Public țintă

Research

Cuprins

Microbiology: Virology.- The Evolution of Gammaretrovirus Restriction Factors in the Mouse.- Herpesvirus Research at the National Institute of Allergy and Infectious Diseases: Thirty Years of Progress.- Why Study Mouse Retroviruses?.- Functions of the Rotavirus RNA Polymerase in Virus Replication.- Human T-Cell Leukemia Virus Type 1, Cellular Transformation, and Adult T-Cell Leukemia.- Microbiology: Human Immunodeficiency Virus (HIV).- Roles for Chemokine Receptors in HIV Pathogenesis.- HIV-1 Accessory Proteins: Crucial Elements for Virus-Host Interactions.- Microbiology: Bacteriology.- Exploring the Cause of Human Q Fever: Recent Advances in Coxiella burnetii Research.- Plague in the 21st Century: Global Public Health Challenges and Goals.- Molecular Biology of Staphylococcal Pathogenesis.- Investigations of Relapsing Fever at Home and Abroad.- Molecular Sleuthing with the Lyme Disease Agent.- Modeling of Acute Respiratory Melioidosis and Glanders.- Microbiology: Mycology.- Cryptococcosis: From Discovering the Natural Reservoir of its Etiology to the Genetic Manipulation of Cryptococcus neoformans: Milestones in Cryptococcal Research by Intramural Investigators at NIAID.- Microbiology: Parasitology.- Lessons from Parasites on CD4+ T-Cell Subset Differentiation and Function.- Molecular Aspects of Parasite – Vector Interactions In Leishmaniasis.- Microbiology: Malaria.- Mosquito Strategies Against Plasmodium: A Tale of Restrained Response and Immune Evasion.- The Plasmodial Surface Anion Channel: A Model Microbial Ion Channel and Target for Antimalarial Drug Development.- Genomics and Genetics of Drug Resistance and Regulation of Malaria Parasite Development.- Immunology: Cellular Immunology.- Modulation of Human Dendritic Cells by Highly Virulent Pathogens.- Making Friends in Out-of-the- Way Places: How Cells of the Immune System Get Together and How They Conduct Their Business as Revealed by Intravital Imaging.- Role of Regulatory/Suppressor T Cells in Immune Responses.- Proliferation versus Contraction of Immune Cells, the Non-Apoptotic Role of Caspase 8 In Immune Homeostasis.- Features of Plasma Cell-Related Neoplasms in Mice.- A Role of IRF8 in Transcriptional Control of B-Cell Development.- Laboratory of Molecular Immunology.- Immunology: The Role of Receptors.- Structure and Function of Immunoreceptors.- Role of the NKG2D Receptor in Health and Disease.- Allergy.- G-Protein-Evoked Signaling Mechanisms in Asthma and Allergic Disease.- Mast Cell Precursors and Signaling Pathways.- Clinical Medicine: Infectious Diseases.- Prion Biochemistry and Therapeutics.- Neutrophils in the Resolution of Infection.- Reactive Oxidant-Dependent Innate Immune Defenses of the Airway Epithelium: The Dual Oxidase-Lactoperoxidase-Thiocyanate System.- Chronic Granulomatous Disease: From Lethal Pediatric Mystery to Complex Chronic Disease.- Pneumonia Virus of Mice (PVM): Exploring Novel Therapeutic Options In a Severe Respiratory Disease Model.- The 1918 InfluenzaPandemic: Pathology and Pathogenesis.- Clinical Medicine: Autoimmune Diseases.- Mind Your Xs and Ys: Genetics of the Autoimmune Disease Systemic Lupus Erythematosus.- A Bench-to-Bedside Trail of Research Leading to the Understanding and Treatment of Ulcerative Colitis.- Clinical Medicine: Vaccines.- Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses.- How Do You Say “B-Cell Biology” In “Vaccinology”: Translational Research In the NIAID.- Malaria Vaccine Development.- The Development of Live-Attenuated Vaccines for Pandemic Influenza.- Targeting the Messenger: Vector-Based Vaccines to Control Leishmania Infection and Transmission.

Caracteristici

Contains individual research contributions by internationally known scientists doing research in the NIAID laboratories Covers new research findings in immunology, infectious diseases, and vaccine research Three-volume set will make the current state-of-the-art advancements of biomedical research available to the scientific community worldwide

Recenzii

From the reviews:“It is a rich and diverse set of information brought together in one place. … This book is a reference resource, useful for any higher education institute or medical facility engaged in any form of biomedical research. Particularly helpful for anyone trying to write NIH grant applications or understand how to fund NIH programmes to complement their own work.” (Maria Zambon, Microbiology Today, January, 2010)

Textul de pe ultima copertă

I N F E C T I O U S D I S E A S E®
Vassil St. Georgiev, Series Editor
National Institute of Allergy and Infectious Diseases, NIH
Volume 2: Impact on Global Health
Vassil St. Georgiev, PhD with Foreword by Antony S. Fauci, MD
National Institute of Allergy and Infectious Diseases, National Institutes of Health, DHHS, Bethesda, MD
For more than 50 years, the mission of the national Institute of Allergy and Infectious Disease (NIAID)has been to conduct and support basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases with the ultimate goal of improving the health of individuals in the United States and around the world. As part of its mission to foster biomedical research and to reduce the burden of human disease, NIAID is committed to encouraging the accelerated translation of biomedical discoveries into effective clinical care and public throughout the world. In pursuit of this goal and its disease-specific scientific objectives, NIAID seeks to broaden its global impact by increasing scientific opportunities and collaborations involving scientists and institutions outside the United States. The ever increasing efforts of NIAID to combat the worldwide HIV/AIDS, malaria, as well as the increasing numbers of humans infected by highly virulent strains of avian influenza in Asia and elsewhere. NIAID is at the forefront of efforts to address these and other international health challenges by supporting programs in approximately 90 countries and to have dramatically increased spending on international activities in the past decade in a clear strategy to not only devote more resources within the United States to the study of diseases with global health importance, but also to develop the capacity for advanced research within resource-poor nations.
Extensive and in-depth, National Institute of Allergy and Infectious Diseases, NIH: Volume 2,Impact on Global Health is a valuable and comprehensive guide providing up-to-date accounts on the state of specific research endeavors in the areas of microbiology and infectious diseases (other than AIDS), HIV/AIDS, allergy, immunology, and transplantation, covering the research portfolios of the NIAID’s extramural divisions of Microbiology and Infectious Diseases, AIDS, and Allergy, Immunology and Transplantation. This volume comprises documents of the United States Government and other research information that is in the public domain. Nevertheless, this volume is not an official U.S. Government publication.
Features
Includes detailed up-to-date overviews of specific research endeavors in microbiology and infectious diseases (other than HIV/AID), HIV/AIDS, allergy, immunology, and transplantation.
Contents
Foreword: Anthony S. Fauci, MD. Part I. Microbiology and Infectious Diseases. Primary Research Areas in Microbiology and Infectious Diseases (non-HIV/AIDS). NIAID International Research Programs: Global Impact: Africa, Asia, Partnerships. Bacterial Diseases. Emerging and Re-Emerging Infectious Diseases. Fungal Diseases. Tropical Medicine and Parasitic Diseases. Virology. Sexually-Transmitted Diseases. Enteric Diseases. Respiratory Diaeases. Streptococcus pneumoniae (Pneumococcal) Disease. Severe Acute Respiratory Syndrome (SARS). Influenza. Tuberculosis. Viral Hepatitis. West Nile Virus. Herpesviruses. Paramyxoviridae: Nipah Virus and Hendra Virus. Arthropod-Borne Viral Encephalitis: Flaviviruses, Aphaviruses, Bunyaviruses. Malaria. Rickettsia: The Typhus Group. Tick-Borne Bacterial, Rickettsial, Spirochetal, and Protozoal Diseases: Lyme Disease,Tick-Borne Rickettsial Diseases, Tularemia, Souther Tick-Associated Rash Illness, Babesiosis, Tick-Borne Relapsing Fever. Defense against Biological Weapons (Biodefense): History of Biological Warfare, Anthrax, Variola major Virus (Smallpox), Yersinia pestis (Plague),Brucellosis, Coxiella burnetii-Q fever, Glanders, Melioidosis, Viral Hemorrhagic Fever: Filoviruses, Viral Hemorrhagic Fever: Bunyaviridae, Viral Hemorrhagic Fever: Arenaviruses, Viral Hemorrhagic Fever: Flaviviruses, Protein Toxin Weapons, Arthropod-Borne Viral Fever and Arthropathy, NIAID Research Agenda in Biodefense Antimicrobial Resistance and Healthcare-Acquired Infections. Genomic and Post-Genomic Research. Drug Development Research. Part II. Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome. Introduction: Human Immunodeficiency Virus (HIV). NIAID: Programs in HIV Prevention: Clinical Trials. NIAID: Programs in HIV/AIDS Therapeutics: Drug Discovery, Preclinical Drug Development, Clinical Research, Resources for Researchers, NIAID Funding Initiatives, Clinical Trials, Other NIH-Funded Clinical Trials Networks, Clinical Trials Guidelines. NIAID: Programs in HIV Vaccines. NIAID: International Involvement in HIV/AIDS Research: Clinical Trial Network Studies- ACTG, HVTN, IMPAACT, INSIGHT, MTN, Non-Clinical Trial Network Studies, Centers for AIDS Research (CFARs), Comprehensive International Program of Research on AIDS (CIPRA), International Databases to Evaluate AIDS (IeDEA), Male Circumcision, NIAID Collaborative International Research, U.S. Military HIV Research Program (USMHRP) Trials funded by NIAID, Other HIV/AIDS Vaccine Related Work, International AIDS Vaccine Initiative (IAVI), Partnership for AIDS Vaccine Evaluation (PAVE), Center for HIV/AIDS Vaccine Immunology (CHAVI), Global HIV Vaccine Enterprise (GHVE), President’s Emergency Plan for AIDS Research (PEPFAR). HIV/AIDS Epidemiology. HIV Therapeutics - Antiretroviral Drugs and Immune-Based Therapies: HIV Reverse Transcriptase, HIV Reverse Transcriptase Inhibitors: Nucleoside Analogues, Nucleotide Analogues: Tenofovir DF, Reverse Transcriptase Inhibitors: Non-Nucleoside Analogues, HIV Protease, HIV Protease Inhibitors, Fixed-Dose Combinations, Viral Entry/Fusion Inhibitors, IntegraseInhibitors, Maturation Inhibitors, HAART: Triple Highly Active Antiretroviral Combinations. Vaccine Development: Vaccine Clinical Trials, Vaccine Discovery and Development/Clinical Research, The Failure of the STEP Trial. Opportunistic Infections: Fungal Infections, Viral Infections, Parasitic Infections, Recent NIAID-Supported Clinical Studies in Opportunistic Infections. Part III. Immunoogy Research. Introduction. Mammalian Host defenses:Innate and Adaptivr Immunity. Immune Adjuvants. Immune Tollerance. Autoimmune Diseases. Mucosal Immune System. The Role of B-Cells. Transplantation. Asthma and Allergic Diseases.