Neuromuscular Junction: Handbook of Experimental Pharmacology, cartea 42
Autor R. E. M. Bowden J. Maglagan Editat de E. Zaimis Autor B. Collier, R. D. Dripps, L. W. Duchen, G. E. Hale Enderby, B. L. Ginsborg, S. Head, F. Hobbiger, D. H. Jenkinson, F. C. MacIntosh, S. E. Smithen Limba Engleză Paperback – 21 mar 2012
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Specificații
ISBN-13: 9783642454783
ISBN-10: 364245478X
Pagini: 768
Ilustrații: XVIII, 748 p.
Dimensiuni: 170 x 244 x 40 mm
Greutate: 1.2 kg
Ediția:Softcover reprint of the original 1st ed. 1976
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology
Locul publicării:Berlin, Heidelberg, Germany
ISBN-10: 364245478X
Pagini: 768
Ilustrații: XVIII, 748 p.
Dimensiuni: 170 x 244 x 40 mm
Greutate: 1.2 kg
Ediția:Softcover reprint of the original 1st ed. 1976
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Handbook of Experimental Pharmacology
Locul publicării:Berlin, Heidelberg, Germany
Public țintă
ResearchCuprins
Introductory Chapter The Neuromuscular Junction: Areas of Uncertainty.- Neuromuscular Block by Prolonged Depolarisation.- Desensitisation.- The Clinical Picture.- The Presence of Other Drugs.- The Importance of the Drug Structure and that of the Acetylcholine Receptor.- Pre-Synaptic or Post-Synaptic Action?.- Closing Remarks.- References.- 1 The Anatomy and Pathology of the Neuromuscular Junction.- A. Introduction.- B. Normal Muscle.- C. Development, Growth, and Plasticity of the Neuromuscular Junction.- D. The Neuromuscular Junction in Disorders of Transmission.- E. The Neuromuscular Junction in Disorders of the Muscle Fibre.- F. Conclusion.- References.- 2 Neurochemistry of Cholinergic Terminals.- A. Introduction.- B. Methods for Extracting and Measuring Acetylcholine.- C. Acetylcholine Synthesis.- D. Acetylcholine Storage.- E. Acetylcholine Release.- F. Acetylcholine Turnover.- G. Removal of Acetylcholine.- H. Axonal Transport of Materials Related to Cholinergic Transmission.- I. Prolonged Neurochemical Changes Resulting from Synaptic Activity.- References.- 3 Transmission of Impulses from Nerve to Muscle.- A. Introduction.- B. The Muscle Fibre and the Action of Acetylcholine.- C. Pre-Synaptic Events.- D. Postscript.- References.- 4A Depolarising Neuromuscular Blocking Drugs.- A. General Introduction.- B. An Introduction to the Pharmacological Actions of Decamethonium at the Neuromuscular Junction.- C. End-Plate Depolarisation by Decamethonium and Suxamethonium in vivo.- D. Effect of Decamethonium, Suxamethonium and Acetylcholine on the Electrical Properties of Single Mammalian Muscle Cells.- E. Depolarisation Versus Desensitisation.- F. Species Differences and Depolarising Neuromuscular Blocking Drugs.- G. Factors which May Modify the Action of Depolarising Neuromuscular Blocking Drugs and Variations Due to Experimental Conditions.- H. Concluding Remarks.- References.- 4B Competitive Neuromuscular Blocking Drugs.- A. Introduction and Terminology.- B. Chemical Structure.- C. Methods Used to Measure Neuromuscular Blockade.- D. Distribution of Competitive Neuromuscular Blocking Drugs.- E. Factors Affecting Duration of Action in Animals and Man.- F. Mechanism of Action at Neuromuscular Junction.- G. Effects at Cholinergic Synapses in the Autonomic Nervous System.- H. Histamine Release in Animals and Man.- J. Miscellaneous Drugs which Cause Muscle Paralysis.- References.- 4C Pharmacology of Anticholinesterase Drugs.- A. Introduction.- B. Morphology and Function of Acetylcholinesterase (AChE).- C. Inhibition of AChE.- D. Actions of Anticholinesterases of the Carbamate and Organophosphate Type and of Anilinium Ions.- General Conclusions.- Appendix I Studies on Frog Muscles.- Appendix II Anticholinesterases and Anilinium Ions Referred to in the Text.- Appendix III An Outline of the Methods Used to Calculate the Quantal Content of the e.p.p. and the Rate of Refilling and Size of the ACh Store in Nerve Terminals.- References.- 5A The Clinician Looks at Neuromuscular Blocking Drugs.- A. Introduction.- B. General Anaesthesia before Neuromuscular Blocking Drugs.- C. Clinical Influence of Neuromuscular Blocking Drugs.- D. Three Possibly Fatal Reactions to Suxamethonium.- E. Less Serious Reactions to Suxamethonium.- F. Personal Technique.- G. Conclusions.- References.- 5B Neuromuscular Blocking Drugs in Man.- A. Introduction.- B. Measurement of Drug Action.- C. Pharmacokinetics of Neuromuscular Blocking Drugs.- D. Action of Neuromuscular Blocking Drugs at the Neuromuscular Junction.- E. Other Actions of Neuromuscular Blocking Drugs.- References.- 5C Twenty Years’ Experience with Decamethonium.- A. Introduction.- B. First Clinical Reports.- C. Analysis of 32000 Administrations of Decamethonium.- D. Assessment.- References.- Author Index.