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Nucleic Acid Switches and Sensors

Editat de Scott K. Silverman
en Limba Engleză Paperback – 9 oct 2011
In this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.
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Specificații

ISBN-13: 9781441942487
ISBN-10: 1441942483
Pagini: 136
Ilustrații: IX, 125 p. 57 illus., 3 illus. in color.
Dimensiuni: 155 x 235 x 7 mm
Ediția:2006
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

Artificial Nucleic Acid Switches and Sensors.- Allosteric Ribozymes as Molecular Switches and Sensors.- Ribozymes and Deoxyribozymes Switched by Oligonucleotides.- Ribozymes Switched by Proteins.- Fluorescence-Signaling Nucleic Acid-Based Sensors.- Natural Nucleic Acid Switches and Sensors.- Protein-Induced RNA Switches in Nature.- Riboswitches as Genetic Control Elements.- Switchable RNA Motifs as Drug Targets.

Caracteristici

The studies described in Nucleic Acid Switches and Sensors demonstrate that interesting and useful molecular-scale switches and sensors can be made out of nucleic acids, by both artificial and natural means