Osteoporosis in Older Persons: Advances in Pathophysiology and Therapeutic Approaches
Editat de Gustavo Duque, Douglas P. Kielen Limba Engleză Paperback – 31 mai 2018
It was just recently that a new syndrome, osteoporosis of advanced age, was recognized as a new entity with its own pathophysiology and potential treatments. Unfortunately, and despite the fact that hip fractures are mostly a consequence of this process, and apart from the first edition of this book, there are few publications about this subject.
The first edition of this book demonstrated that there is a need to understand the particular features of osteoporosis in older persons, which is the main aim of this book. The institutions where the authors are affiliated are highly recognized as the main centers in aging bone research. As an innovation, the second edition includes some aspects of muscle and bone interaction focusing of the impact of age-related muscle loss (sarcopenia) on the pathogenesis of falls and fractures in older persons. As in the previous edition, this book is expected to be the reference guide for geriatricians, gerontologists, and bone biologists as well as medical trainees in order to understand the mechanisms of senile osteoporosis with a practical approach to the treatment of its consequences.
| Toate formatele și edițiile | Preț | Express |
|---|---|---|
| Paperback (2) | 361.87 lei 6-8 săpt. | |
| SPRINGER LONDON – 15 noi 2009 | 361.87 lei 6-8 săpt. | |
| Springer International Publishing – 31 mai 2018 | 962.26 lei 38-44 zile | |
| Hardback (2) | 370.99 lei 6-8 săpt. | |
| SPRINGER LONDON – 22 ian 2008 | 370.99 lei 6-8 săpt. | |
| Springer International Publishing – 20 iul 2016 | 679.16 lei 38-44 zile |
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Specificații
ISBN-13: 9783319798691
ISBN-10: 3319798693
Pagini: 282
Ilustrații: XX, 282 p. 49 illus., 17 illus. in color.
Dimensiuni: 178 x 254 mm
Ediția:Softcover reprint of the original 2nd ed. 2016
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
ISBN-10: 3319798693
Pagini: 282
Ilustrații: XX, 282 p. 49 illus., 17 illus. in color.
Dimensiuni: 178 x 254 mm
Ediția:Softcover reprint of the original 2nd ed. 2016
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland
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Cuprins
1. Biology of Bone.- 2. Aging and Bone.- 3. Calciotropic Hormones.- 4. The Muscle-Bone Connection.- 5. Sex Steroids and Aging Bone.- 6. Animal Models for Senile Osteoporosis.- 7. Senile Osteoporosis as a Geriatric Syndrome.- 8. Genetics of Osteoporosis in Older Age.- 9. Fracture Epidemiology in Individuals 75+.- 10. Falls as a Geriatric Syndrome: Mechanisms and Risk Identification .- 11. Medical Treatment of Age Related Osteoporosis.- 12. Non Pharmacological Treatment and Prevention of Falls and Fractures.- 13. Fracture Liaison Services.- 14. Treatment of Osteoporosis in Long-Term Care.- 15. Fracture Care in the Elderly.- 16. The Orthogeriatrics Model of Care.
Notă biografică
Gustavo Duque, MD, PhD Ageing Bone Research Program Sydney Medical School Nepean The University of Sydney (Australia)
Douglas P. Kiel, MD, MPH Institute for Aging Research Hebrew SeniorLife Harvard Medical School (USA)
Textul de pe ultima copertă
This second edition brings together the latest informationabout the pathophysiology and new therapeutic alternatives for osteoporosis ofadvanced age. Written by highly recognised clinicians and basic scientists inthe field of aging bone research, this book includes aspects of muscle and boneinteraction focusing on the impact of age-related muscle loss (sarcopenia) onthe pathogenesis of falls and fractures in older persons.
Osteoporosis in OlderPersons- Advances in Pathophysiology and Therapeutic Approach, Second Edition,aids the reader in understanding the mechanisms of senile osteoporosis with apractical approach to the treatment of its consequences. It is the perfectreference guide for geriatricians, gerontologists and bone biologists, as wellas medical trainees.
Osteoporosis in OlderPersons- Advances in Pathophysiology and Therapeutic Approach, Second Edition,aids the reader in understanding the mechanisms of senile osteoporosis with apractical approach to the treatment of its consequences. It is the perfectreference guide for geriatricians, gerontologists and bone biologists, as wellas medical trainees.
Caracteristici
This book will contain the basic biology of aging bone including the potential links between aging and the changes in bone biology This book will integrate the subject of falls with the one on fractures Figures showing the potential therapeutic targets in bone to prevent and treat osteoporosis will be complemented by a complete review on the current treatments Future treatments will be also included explaining their biological basis as well as their potential indications
Descriere
Descriere de la o altă ediție sau format:
Although osteoporosis has been de? ned as “a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk,” it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized “osteoporosis of old age” and distinguished it from osteoporosis associated with the postme- pausal state, as well as from osteoporosis from disuse, osteoporosis from malnutrition, and other forms of osteoporosis. He nevertheless pointed out that it was unclear how much of osteoporosis is due to old age per se, in view of the fact that “in many cases osteoporosis of disuse, of malnutrition, of the postmenopausal state and of senility are inseparably superimposed. ” In this volume, Duque and Kiel have gathered an international panel of experts to highlight the unique features of senile osteoporosis and cons- eration of this disease spans the very basic through the clinical and the epidemiologic. As an organ which harbors stem cells, bone may clearly in? uence not only its own regeneration but also the regeneration of other tissues, notably the hematopoietic system.
Although osteoporosis has been de? ned as “a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of bone tissue leading to enhanced bone fragility and a consequent increase in fracture risk,” it is not clear that osteoporosis represents a single disease as much as a similar response of bone to different pathophysiologies. In the 1940s Fuller Albright and colleagues recognized “osteoporosis of old age” and distinguished it from osteoporosis associated with the postme- pausal state, as well as from osteoporosis from disuse, osteoporosis from malnutrition, and other forms of osteoporosis. He nevertheless pointed out that it was unclear how much of osteoporosis is due to old age per se, in view of the fact that “in many cases osteoporosis of disuse, of malnutrition, of the postmenopausal state and of senility are inseparably superimposed. ” In this volume, Duque and Kiel have gathered an international panel of experts to highlight the unique features of senile osteoporosis and cons- eration of this disease spans the very basic through the clinical and the epidemiologic. As an organ which harbors stem cells, bone may clearly in? uence not only its own regeneration but also the regeneration of other tissues, notably the hematopoietic system.
Recenzii
From the reviews:
"The authors of this multiauthored book bring together new information on the molecular biology of bone physiology in this examination of osteoporosis in older persons. … The intended audience includes all health practitioners who treat older patients with osteoporosis. Research scientists in the area will find this book useful as well. … This book’s demonstration of the complex relationship of bone health to adipose tissue and several powerful hormones will stimulate new thinking in the area of osteoporosis." (David O. Staats, Doody’s Review Service, August, 2008)
"This is a simply outstanding compilation that provides a clear and concise review of the effect age has on the skeleton at the molecular/genetic level, in animal models as well as humans. … It provides clinicians with an overview of cellular mechanisms leading to bone loss and researchers with insight into the clinical consequences of age-related skeletal change in older adults. That such a text has not previously been written and become a reference standard among clinicians, geriatricians, and researchers … ." (Neil Binkley, JAMA, Vol. 300 (11), September, 2008)
"The authors of this multiauthored book bring together new information on the molecular biology of bone physiology in this examination of osteoporosis in older persons. … The intended audience includes all health practitioners who treat older patients with osteoporosis. Research scientists in the area will find this book useful as well. … This book’s demonstration of the complex relationship of bone health to adipose tissue and several powerful hormones will stimulate new thinking in the area of osteoporosis." (David O. Staats, Doody’s Review Service, August, 2008)
"This is a simply outstanding compilation that provides a clear and concise review of the effect age has on the skeleton at the molecular/genetic level, in animal models as well as humans. … It provides clinicians with an overview of cellular mechanisms leading to bone loss and researchers with insight into the clinical consequences of age-related skeletal change in older adults. That such a text has not previously been written and become a reference standard among clinicians, geriatricians, and researchers … ." (Neil Binkley, JAMA, Vol. 300 (11), September, 2008)