Pathophysiology of Cardiovascular Disease de Naranjan S. Dhalla

Pathophysiology of Cardiovascular Disease: Progress in Experimental Cardiology, cartea 10

Naranjan S. Dhalla

Heinz Rupp

Aubie Angel

Grant N. Pierce

Pathophysiology of Cardiovascular Disease has been divided into four sections that focus on heart dysfunction and its associated characteristics (hypertrophy, cardiomyopathy and failure); vascular dysfunction and disease; ischemic heart disease; and novel therapeutic interventions.
This volume is a compendium of different approaches to understanding cardiovascular disease and identifying the proteins, pathways and processes that impact it.

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Cuprins

1. Septic Cardiomyopathy.- 2. Mitochondrial Function—A Limiting Factor in Heart Failure?.- 3. Myosin Heavy Chain Isoforms Modulate Motor Function of Cardiac Myosin by Changing Crossbridge Kinetics.- 4. Role of Reactive Oxygen Species in the Regulation of Cardiac Myocyte Phenotype.- 5. Functional Significance of Ryanodine Receptor-Mediated Calcium Leaks in Sarcoplasmic Reticulum Membranes.- 6. Cell-Cell and Cell-Extracellular Matrix Interactions in Cardiomyopathy.- 7. Role of the Phosphoinositide 3-Kinase Pathway in Cardiac Hypertrophy.- 8. Role of Ras/GTPase and Calcium/Calmodulin-dependent Protein Kinase II in the Signal Transduction Mechanisms Involved in Hyperthermic Preconditioning.- 9. Interactions of the Cyclic AMP and Nitric Oxide Pathways in Cardiac Fibroblasts.- 10. Do Humoral and Mechanical Stimulation of Cardiomyocytes Share Common Transduction Pathways?.- 11. Differential Inhibition by the Phosphatase Inhibitor Cantharidin of the Antiadrenergic Effect of Endothelin-1 and Carbachol in the Canine Ventricular Myocardium.- 12. Factors Involved in Self and Drug-Induced Spontaneous Ventricular Defibrillation: Intra and Inter Species Variations.- 13. Cardiac ATP-Sensitive Potassium Channel: A Bi-Functional Channel/Enzyme Multimer.- 14. Measurement of Cytosolic pH Simultaneously with Isometric Tension in Canine Trabeculae.- 15. Redox Regulation of Ischemic Heart Disease.- 16. Cell Biology of Acute Reperfusion Injury.- 17. Reactive Oxygen Species, Na+/H+ Exchange and Ca2+ Overload During Myocardial Ischemia/Reperfusion Injury: The Paradox Explained?.- 18. Calcium Signalling During Acute Myocardial Ischemia: New Insights from Optical Mapping Techniques.- 19. Effects of Ischemia on Cardiomyocyte Connexin-43 Distribution and Phosphorylation Studied in in vivo and invitro Models.- 20. Temperature Dependence of Ischemic Preconditioning.- 21. Mechanism of Cardioprotective Effect of Remote Aortic Preconditioning.- 22. Inhibition of Degranulation of Resident Cardiac Mast Cells May Prevent Ischaemia and Reperfusion-Induced Myocardial Injury.- 23. Mechanisms of Cardioprotection against Ischemia Reperfusion Injury.- 24. Modulation of Arachidonic Acid Metabolism by Phorbol 12-Myristate 13-Acetate in Monocytes and Myocytes.- 25. Endothelium-Derived Hyperpolarizing Factor(s). Does it exist and What Role Does it Play in the Regulation of Blood Flow?.- 26. Cytokinesis in Smooth Muscle.- 27. ADP-Ribosylation and the Cardiovascular System.- 28. Influence of the Myocardium Contractile State in the Coronary Venous Flow Deviation Phenomenon.- 29. Natriuretic Peptides and Endothelin in Aortic Stenosis and Heart Transplantation.- 30. Activation of Mitogen-Activated Protein Kinases and Protein Kinase B/Akt Signaling by Oxidative Stress in Vascular Smooth Muscle Cells: Involvement in Vascular Pathophysiology.- 31. Preconditioning and Myocardial Angiogenesis.- 32. The Arachidonic Acid Cascade: Thromboxane A2 Antagonism and Synthetase Inhibition in Experimental Myocardial Infarction.- 33. Receptors and Channels of Nuclear Envelope Membranes as a New Target for Drug Action.- 34. SMAD Cofactors/Corepressors in the Fibrosed Post-MI Heart: Possible Therapeutic Targets.- 35. Phytoestrogens and Cardiovascular Disorders.- 36. Non-Conventional Long-Lasting Cardioprotection Induced by Chronic Exposure to Ambient Heat.- 37. Fetal and Neonatal Cardiomyocyte Transplantation for the Treatment of Myocardial Infarction.- 38. Cellular Cardiomyoplasty: The Role of Bone Marrow Stromal Cells in Myocardial Tissue Regeneration.- 39. Xenotransplantation: An Overview.- 40. Assessment of Myocardial Injury Using Magnetic Resonance Imaging.- 41. Magnetic Resonance in the Assessment and Development of Surgical Strategies for Protecting the Brain during Cardiovascular Surgery.- 42. Heart Failure Recovery with Mechanical Circulatory Support.