Autografts are considered to have the best osteogenic, osteoconductive and osteoinductive properties thereby providing the most efficient structure for reconstruction of bony defects, which has been confirmed by histomorphometric analysis. Utilizing autografts, bone regeneration is optimized during the initial bone healing period due to the presence of particulate grafts with excellent osteoconductivity. Management of soft-tissue defects usually include autogenous sources to achieve closure of defects and increase the soft-tissue volume.Autogenous grafts (bone and soft tissue) remain the gold standard for periodontal regeneration, but due to its side effects, such as, donor site morbidity, limited availability of the material, susceptibility to microbial contamination, technique sensitivity, it is used less commonly in case of bone grafting while in case of soft tissue grafting it is still being used. The term ¿gold standard¿ implies a well-defined and consistent standard of harvesting procedure.