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Pharmacokinetics in Drug Discovery and Development

Editat de Ronald D. Schoenwald
en Limba Engleză Hardback – 6 mar 2002
Pharmacokinetics has evolved from its origin into a complex discipline with numerous subspecialties and applications in patient management, drug development, and regulatory issues. This expansion has made it difficult for any one individual to become a full-fledged expert in all areas. Fulfilling the need for a wide-ranging guide to the many existing subspecialties in this field, Pharmacokinetics in Drug Discovery and Development details the different areas in the field providing the ideal comprehensive, quick access text and reference.

After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section's theme. Covering the many sub-disciplines and providing pharmacokinetic concepts, terminology, and approaches, Pharmacokinetics in Drug Discovery and Development serves as a resource for professionals throughout this field.
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Specificații

ISBN-13: 9781566769730
ISBN-10: 1566769736
Pagini: 440
Ilustrații: 50 b/w images and 3 halftones
Dimensiuni: 156 x 234 x 30 mm
Greutate: 0.97 kg
Ediția:New.
Editura: CRC Press
Colecția CRC Press

Public țintă

Professional

Cuprins

BASIC PRINCIPLES: Basic Principles. INDUSTRIAL AND REGULATORY APPLICATIONS: PK/PD Approach. Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development. Phase I, II, and III FDA Submissions. Bioavailability and Bioequivalence. CLINICAL APPLICATIONS: General Approaches to Clinical Pharmacokinetic Monitoring. Aminoglycosides and Other Antibiotics. Cardiovascular Agents. Psychotropic Agents. Theophylline. Anticonvulsant Agents. RESEARCH APPLICATIONS: Classical Modeling. Non-compartmental Modeling. Physiologically-Based Pharmacokinetic Models. Population Pharmacokinetics. The Linear Systems Approach.

Recenzii

"well written, making many of the approaches understandable even if, like me, the reader is not mathematically gifted. Certainly, this section has stimulated my desire to learn more, and like the Clinical Application section, I will be referring to it regularly"
- Peter Lawrence, AstraZeneca, UK, BTS Newsletter, Spring 2003

"The authors intend to provide a basic understanding and overview of numerous areas within pharmacokinetics...For anyone with a solid initial training in the field, however, this book should function quite well as a refresher on familiar areas and, more to the intended point, as an introduction to subspecialty areas."
-Gregory Reed, PhD, University of Kansas Medical Center

Descriere

From basic principles to industrial and regulatory applications to clinical and research applications, this book provides a comprehensive review of all the subspecialties in the field. After an introduction of basic principles, the book is divided into sections that cover industrial and regulatory applications, clinical applications, and research applications. The following sections cover such topics as PK/PD approaches, clinical pharmacokinetic monitoring, population pharmacokinetics, linear systems approaches, and more. Fourteen authors, each an expert in his/her area of expertise, provide an extensive background into the subspeciality with emphasis on the section's theme.