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Pharmacology of Potassium Channels de Nikita Gamper

Pharmacology of Potassium Channels: Handbook of Experimental Pharmacology, cartea 267

Editat de Nikita Gamper, KeWei Wang
en Limba Engleză Paperback – 29 sep 2022
The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery.
This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. 
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Specificații

ISBN-13: 9783030840549
ISBN-10: 3030840549
Pagini: 545
Ilustrații: VIII, 545 p. 70 illus.
Dimensiuni: 155 x 235 mm
Ediția:1st ed. 2021
Editura: Springer International Publishing
Colecția Springer
Seria Handbook of Experimental Pharmacology

Locul publicării:Cham, Switzerland

Cuprins

Comparison of K+ Channel families.-  High-resolution structures of K+ channels.- Pharmacological approaches to studying potassium channels.- Cardiac K+ channels and channelopathies.- Cardiac hERG K+ channel as safety and pharmacological target.- Pharmacology of A-type K+ channels.- Kv7 channels and hyperexcitability disorders.- Pharmacological activation of neuronal voltage-gated Kv7/KCNQ/M-channels for potential therapy of epilepsy and pain.- Potassium channels in cancer.- Kir channel molecular physiology, pharmacology and therapeutic implications.- The pharmacology of ATP-sensitive K+ channels (KATP).- Calcium-activated K+ channels (KCa) and therapeutic implications.- The Pharmacology of two-pore domain potassium channels.- Control of biophysical and pharmacological properties of potassium channels by ancillary subunits.- Peptide toxins targeting KV channels.- Therapeutic antibodies targeting potassium ion channels.

Textul de pe ultima copertă

The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology. 

Caracteristici

Broadens the understanding of the molecular design, biological functions and role in disease of potassium channels Critically reviews state-of-the art in the ongoing revolution in structural biology + pharmacology of potassium channels Offers insights into cutting-edge therapeutic strategies targeting potassium channels for treatment of severe diseases