Anxiety is the most widespread psychiatric disorder and generalized anxiety disorder is the most common disease seen in the primary care setting. Currently there are a number of anxiolytic drugs available in the market for treatment of anxiety disorders such as Benzodiazepines like Diazepam, Chlordiazepoxide, Alprazolam, Betablockers like Propranolol and H1 Antihistaminics like Hydroxyzine. Some of the newer anxiolytics like Azapirone and Buspirone is marketed as better anxiolytic drug than the traditional drugs. Buspirone is promoted as a better drug for anxiety, as it does not cause any sedation, tolerance or physical dependence.This is an observational study undertaken, between October 2009 to March 2010, at the Psychiatric inpatient Department of Manipal Teaching Hospital. The Z test was used to examine the difference between different variables and strength of the relationship with logistic regression. p > 0.05 is considered as statistically significant.This is the first study on anxiolytic drugs in psychiatry inpatients from Nepal.This book is essential for the general population and the researchers.