Cantitate/Preț
Produs
Total produse
Vezi coșul
Phosphoinositide 3-kinase in Health and Disease: Volume 1 de Christian Rommel

Phosphoinositide 3-kinase in Health and Disease: Volume 1: Current Topics in Microbiology and Immunology, cartea 346

Editat de Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt
en Limba Engleză Paperback – 7 noi 2012
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here
Citește tot Restrânge

Toate formatele și edițiile

Toate formatele și edițiile Preț Express
Paperback (2) 134022 lei  6-8 săpt.
  Springer Berlin, Heidelberg – 7 noi 2012 134022 lei  6-8 săpt.
  Springer Berlin, Heidelberg – 3 dec 2012 134022 lei  6-8 săpt.
Hardback (2) 134455 lei  6-8 săpt.
  Springer Berlin, Heidelberg – oct 2010 134455 lei  6-8 săpt.
  Springer Berlin, Heidelberg – oct 2010 135235 lei  6-8 săpt.

Din seria Current Topics in Microbiology and Immunology

  • Hantaviruses
    Preț: 38779 lei
  • 18% Epstein Barr Virus Volume 1: One Herpes Virus: Many Diseases
    Preț: 91372 lei
  • 5% Epstein Barr Virus Volume 2: One Herpes Virus: Many Diseases
    Preț: 106673 lei
  • Marburg- and Ebolaviruses: From Ecosystems to Molecules
    Preț: 49976 lei
  • 5% Type IV Secretion in Gram-Negative and Gram-Positive Bacteria
    Preț: 31970 lei
  • 5% Coordinating Organismal Physiology Through the Unfolded Protein Response
    Preț: 31742 lei
  • 5% mRNA Vaccines
    Preț: 96779 lei
  • 18% Viral Fitness and Evolution: Population Dynamics and Adaptive Mechanisms
    Preț: 106240 lei
  • 5% T Cell Hybridomas: A Workshop at the Basel Institute for Immunology
    Preț: 68108 lei
  • 5% Tumorviruses, Neoplastic Transformation and Differentiation
    Preț: 67724 lei
  • 5% Current Topics in Microbiology and Immunology: Volume 102
    Preț: 67396 lei
  • 5% Retroviruses 1
    Preț: 67396 lei
  • 5% New Developments in Diagnostic Virology
    Preț: 68506 lei
  • 5% Mouse Mammary Tumor Virus
    Preț: 34186 lei
  • 5% Retroviruses 2
    Preț: 67621 lei
  • 5% Methylation of DNA
    Preț: 73597 lei
  • 15% The Molecular Biology of Adenoviruses I: 30 Years of Adenovirus Research 1953–1983
    Preț: 60798 lei
  • 5% The Molecular Biology of Adenoviruses 2: 30 Years of Adenovirus Research 1953–1983
    Preț: 68108 lei
  • 5% The Molecular Biology of Adenoviruses 3: 30 Years of Adenovirus Research 1953–1983
    Preț: 34242 lei
  • 5% Retroviruses 3
    Preț: 67222 lei
  • 5% Oncogenes in B-Cell Neoplasia: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 5–7, 1984
    Preț: 68161 lei
  • 5% Current Topics in Microbiology and Immunology
    Preț: 68039 lei
  • 5% Human T-Cell Leukemia Virus
    Preț: 68126 lei
  • 5% Iridoviridae
    Preț: 67568 lei
  • 5% The Biology of Trypanosomes
    Preț: 67621 lei
  • 5% Genetic Approaches to Microbial Pathogenicity
    Preț: 68230 lei
  • 5% Images of Biologically Active Structures in the Immune System: Their Use in Biology and Medicine
    Preț: 67396 lei
  • 5% Parasite Antigens in Protection, Diagnosis and Escape
    Preț: 35145 lei
  • 5% Bacteria and Complement
    Preț: 67656 lei
  • 5% The BALB/c Mouse: Genetics and Immunology
    Preț: 68054 lei
  • 5% Retroviruses 4
    Preț: 67120 lei
  • 5% Genetic Control of the Susceptibility to Bacterial Infection
    Preț: 67587 lei
  • 5% Protein Secretion and Export in Bacteria
    Preț: 67779 lei
  • 5% Specificity and Function of Clonally Developing T Cells
    Preț: 68437 lei
  • 5% The Wild Mouse in Immunology
    Preț: 68907 lei
  • 5% Current Topics in Microbiology and Immunology 128
    Preț: 67258 lei
  • 5% Current Topics in Microbiology and Immunology
    Preț: 67794 lei
  • 5% Peptides as Immunogens
    Preț: 67047 lei
  • 5% The Molecular Biology of Baculoviruses
    Preț: 67533 lei
  • 5% Mechanisms in B-Cell Neoplasia: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD,USA,March 24–26,1986
    Preț: 68766 lei
  • 5% Arenaviruses: Genes, Proteins, and Expression
    Preț: 67222 lei
  • 5% Arenaviruses: Biology and Immunotherapy
    Preț: 67951 lei
  • 5% Differentiation of B Lymphocytes
    Preț: 67429 lei
  • 5% The Molecular Biology of Bacterial Virus Systems
    Preț: 34119 lei
  • 5% Genetics of Immunological Diseases
    Preț: 35558 lei
  • 15% Carbohydrate-Protein Interaction
    Preț: 60349 lei
  • 5% Cytotoxic Effector Mechanisms
    Preț: 67239 lei
  • 5% Mechanisms in B-Cell Neoplasia 1988: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, March 23–25, 1988
    Preț: 68579 lei
  • 15% Human Retrovirology: Facts and Concepts
    Preț: 60117 lei

Preț: 134022 lei

Preț vechi: 141076 lei
-5% Nou

Puncte Express: 2010
Preț estimativ în valută:
25654€ • 27583$ • 21386£

Carte tipărită la comandă

Livrare economică 20 decembrie 24 - 03 ianuarie 25

 Adaugă în coș

Wish list
Gift list
Am citit!
Adaugă în listă
Preluare comenzi: 021 569.72.76

Specificații

ISBN-13: 9783642265228
ISBN-10: 3642265227
Pagini: 320
Ilustrații: X, 310 p. 29 illus., 23 illus. in color.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.45 kg
Ediția:2011
Editura: Springer Berlin, Heidelberg
Colecția Springer
Seria Current Topics in Microbiology and Immunology

Locul publicării:Berlin, Heidelberg, Germany

Public țintă

Research

Cuprins

PI3K – From the Bench to the Clinic and Back.- PI3K Book Introduction.- PDK1: The major transducer of PI 3-Kinase actions.- Protein Kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway.- Regulatory subunits of class IA PI3K.- The Regulation of Class IA PI 3-kinases by Inter-Subunit Interactions.- Phosphoinositide signalling pathways in metabolic regulation.- Role of RAS in the regulation of PI 3-kinase.- More than just kinases: The scaffolding function of PI3K.- PI3K signalling in neutrophils.- PI 3-kinase p110beta regulation of platelet integrin alphaIIbbeta3.- PI3Ks in lymphocyte signalling and development.- PI3 kinase regulation of skeletal muscle hypertrophy and atrophy.- Taking PI3Kdelta and PI3Kgamma one step ahead – Dual active PI3Kdelta/gamma inhibitors for the treatment of immune-mediated inflammatory diseases.- Oncogenic Mutations of PIK3CA in Human Cancers.- Structural Effects of Oncogenic PI3Kalpha Mutations.- Comparing the roles of the p110alpha and p110beta isoforms of PI3K in signaling and cancer.- Phosphatidylinositol 3-kinase (PI3K): The oncoprotein.- AKT Signaling in Physiology and Disease.- Faithfull modeling of PTEN loss driven diseases in the mouse.- PI3K as a target for therapy in haematological malignancies.- Clinical development of Phosphatidylinositol-3 kinase pathway inhibitors.- New inhibitors of the PI3K-Akt-mTOR pathway: Insights into mTOR signaling from a new generation of Tor kinase domain inhibitors (TORKinibs).- Small molecule inhibitors of the PI3-kinase family.- Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.- Subject index.

Textul de pe ultima copertă

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.

Caracteristici

PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target