This book is an up-to-date guide on pluripotent stem cells. Several types of stem cells are being examined for their regenerative ability. Stem cells have developed a great amount of excitement among the clinicians, researchers and the public alike. Slight advantage because of transplanting autologous stem cells in several distinct clinical conditions has been suggested to be a progress factor effect rather than actual regeneration. In comparison, several pre-clinical analyses have been carried out, with the help of differentiated cells from induced pluripotent stem cells or embryonic stem cells have displayed functional advancement, promise and zero signs of teratoma formation. This book is a compilation of studies, starting with an introduction to the pluripotent stem cells and encompassing insightful information regarding the latest standing on the pluripotent stem cells biology and elucidation of the potential therapeutic implications and ethical concerns of these in vitro developed cells in different diseases, along with the related pros and cons are covered in this book.