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Polycyclic Aromatic Hydrocarbons: Chemistry and Carcinogenicity: Cambridge Monographs on Cancer Research

Autor Ronald G. Harvey
en Limba Engleză Paperback – 15 iun 2011
Polycyclic aromatic hydrocarbons, many of which have been identified as potent human carcinogens, occur widely in the environment as a result of incomplete combustion of fossil fuels and other organic matter. Major sources of emissions arise from wood and coal burning, automobiles, heat and power plants, and refuse burning. Their widespread occurrence in the air and in food and water underlines the importance of understanding their role as causes of human cancer. This 1991 volume was the first to review the chemical properties of these carcinogens and to relate their carcinogenic activity to their metabolic by-products within the body. The emphasis throughout is on those recent findings, newer methods and techniques which helped to illuminate the process of carcinogenesis. The volume is suitable for anyone with a professional interest in the chemistry and metabolism of polycyclic aromatic hydrocarbons, environmental chemistry and chemical carcinogenesis.
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Specificații

ISBN-13: 9780521292047
ISBN-10: 0521292042
Pagini: 414
Dimensiuni: 152 x 229 x 23 mm
Greutate: 0.6 kg
Editura: Cambridge University Press
Colecția Cambridge University Press
Seria Cambridge Monographs on Cancer Research

Locul publicării:Cambridge, United Kingdom

Cuprins

Preface; 1. Nomenclature; 2. Environmental occurrence and cancer; 3. Structure-activity relationships; 4. Metabolic activation, DNA binding, and mechanisms of carcinogenesis; 5. Molecular properties of polyarenes; 6. Chemical reactivity; 7. General synthetic methods; 8. Alterant tetracyclic polyarenes; 9. Alterant pentacyclic polyarenes; 10. Alternant hexacylic polyarenes; 11. Nonalternant polyarenes; 12. Arene oxides and imines; 13. Dihydrodiols; 14. Diol epoxides; 15. Other oxidized metabolites; Index.

Descriere

This 1991 volume was the first to review the chemical properties of the carcinogenic polycyclic aromatic hydrocarbons.