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Cancer of the Esophagus: Approaches to the Etiology: Cambridge Monographs on Cancer Research

Autor Valda M. Craddock
en Limba Engleză Paperback – 11 mar 2009
The book deals briefly with the normal structure, functioning and biochemistry of the esophagus and with the histological and genetic changes accompanying the development of esophageal cancer in humans and animals. Factors implicated in causing esophageal cancer are described in relation to its very dramatic epidemiology. Thus dietary deficiencies and consumption of foods contaminated by Fusaria mycotoxins are discussed in connection with the extremely high incidence of the disease in certain sharply demarcated regions in China and South Africa, and alcohol and tobacco use are discussed in relation to the epidemiology in Europe and USA. Other hazards mentioned include opium in Iran, betel nut in Asia and bracken in Japan. The sole group of chemicals known to be very potent esophageal carcinogens in animal experiments, the nitrosamines, are described especially in terms of the widespread human exposure.
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Specificații

ISBN-13: 9780521102582
ISBN-10: 0521102588
Pagini: 300
Dimensiuni: 152 x 229 x 17 mm
Greutate: 0.44 kg
Editura: Cambridge University Press
Colecția Cambridge University Press
Seria Cambridge Monographs on Cancer Research

Locul publicării:Cambridge, United Kingdom

Cuprins

1. Introduction: the problem, incidence, etiology. A working hypothesis; 2. Biology of the esophagus; 3. Esophageal carcinogenesis; 4. Epidemiology; 5. Chemicals carcinogenic for the esophagus: the nitrosamines; 6. Alcoholic beverages and tobacco; 7. Plant products: phenolics, tannins, tea; 8. Plant products: opium, silica, bracken, dihydrosafrole; 9. Molds and mycotoxins; 10. Dietry deficiencies: micronutrients, fresh plant food and protective factors; 11. Possible mechanisms involved in carcinogenesis.

Descriere

The book deals with the esophagus and with the histological and genetic changes accompanying the development of esophageal cancer in humans and animals.