Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease
Editat de Deric L. Wheeler, Yosef Yardenen Limba Engleză Hardback – 26 noi 2014
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Specificații
ISBN-13: 9781493920525
ISBN-10: 1493920529
Pagini: 440
Ilustrații: XVII, 440 p. 56 illus., 51 illus. in color.
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.82 kg
Ediția:2015
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 1493920529
Pagini: 440
Ilustrații: XVII, 440 p. 56 illus., 51 illus. in color.
Dimensiuni: 155 x 235 x 25 mm
Greutate: 0.82 kg
Ediția:2015
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
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Public țintă
ResearchDescriere
Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade they became the Number 1 targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in human, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to The Receptor Tyrosine Kinase Family, which refers to specific subfamilies of RTKs, along with their unique landmarks.
Cuprins
The Eukaryotic Protein Kinase Superfamily.- Evolution of Receptor Tyrosine Kinases.- RTKs in Invertebrates: Lessons in Signal Transduction.- Cell Signaling by Receptor Tyrosine Kinases.- Nuclear Signaling of Receptor Tyrosine Kinases.- Computational and Modeling Aspects of RTK Networks.- Endocytosis of Receptor Tyrosine Kinases.- Structural Features of the Ligand-Binding Extracellular Domain.- Structural Features of the Kinase Domain.- Targeting RTKs in Cancer.- Mouse Models of Receptor Tyrosine Kinases.
Notă biografică
Dr. Deric Wheeler received an M.S. in pathology from the University of Iowa and a Ph.D. in cancer biology from the University of Wisconsin. He conducted his postdoctoral training at the Fred Hutchinson Cancer Research Center in Seattle, WA, and at the University of Wisconsin School of Medicine and Public Health in Madison, where he eventually transitioned to faculty as an assistant professor in the department of human oncology. Dr. Wheeler’s lab research centers on resistance to molecular targeting agents and the role of subcellular localization of receptor tyrosine kinases and their roles in oncogenesis.
Dr. Yosef Yarden received a Ph.D. in molecular biology from the Weizmann Institute of Science in Rehovot, Israel. He completed postdoctoral training at Genentech, Inc. in San Francisco and at the Massachusetts Institute of Technology in Cambridge. He returned to the Weizmann Institute of Science first as an assistant professor and then later as a full professor. His past administrative responsibilities at the Weizmann Institute include Dean of the Faculty of Biology, Vice-President for Academic Affairs, Director of the M.D. Moross Institute for Cancer Research, and Dean of the Feinberg Graduate School. Dr. Yarden’s lab research centers on the roles played by growth factors and receptor tyrosine kinases in tumor progression.
Dr. Yosef Yarden received a Ph.D. in molecular biology from the Weizmann Institute of Science in Rehovot, Israel. He completed postdoctoral training at Genentech, Inc. in San Francisco and at the Massachusetts Institute of Technology in Cambridge. He returned to the Weizmann Institute of Science first as an assistant professor and then later as a full professor. His past administrative responsibilities at the Weizmann Institute include Dean of the Faculty of Biology, Vice-President for Academic Affairs, Director of the M.D. Moross Institute for Cancer Research, and Dean of the Feinberg Graduate School. Dr. Yarden’s lab research centers on the roles played by growth factors and receptor tyrosine kinases in tumor progression.
Textul de pe ultima copertă
Receptor tyrosine kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases, and over the last decade have become the number one targets of cancer drugs. Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease systematically covers, for the first time, the shared structural and functional features of the RTK family. Understanding the evolutionary origin of the 58 RTKs, their roles in invertebrates and in humans, as well as downstream signaling pathways, is essential for fundamental research and for attempts to develop pharmacological agents able to enhance or intercept their actions. The assembly of chapters written by experts underscores commonalities and is an ideal companion volume to The Receptor Tyrosine Kinase Family, which refers to specific subfamilies of RTKs, along with their unique landmarks.
Caracteristici
Leading scientists and researcher providing cutting-edge data
A comprehensive resource that summarizes what we know about receptor tyrosine kinases
An incredible resource to researchers and clinicians and would be utilized by a large audience including, professors, postdocs, graduate students, and scientists in both academic science and industry
Includes supplementary material: sn.pub/extras
A comprehensive resource that summarizes what we know about receptor tyrosine kinases
An incredible resource to researchers and clinicians and would be utilized by a large audience including, professors, postdocs, graduate students, and scientists in both academic science and industry
Includes supplementary material: sn.pub/extras
Recenzii
“An in depth study of the RTK families in 19 chapters. … Clearly written and with extensive references after each chapter. For endocrinologists, molecular biologists and oncologists.” (Pediatric Endocrinology Reviews (PER), Vol. 13 (3), March, 2016)