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Redox-Active Therapeutics de Ines Batinić-Haberle

Redox-Active Therapeutics: Oxidative Stress in Applied Basic Research and Clinical Practice

Editat de Ines Batinić-Haberle, Júlio S. Rebouças, Ivan Spasojević
en Limba Engleză Hardback – 24 oct 2016
This essentialvolume comprehensively discusses redox-active therapeutics, focusingparticularly on their molecular design, mechanistic, pharmacological andmedicinal aspects.  The first section of the book describes the basicaspects of the chemistry and biology of redox-active drugs and includes a briefoverview of the redox-based pathways involved in cancer and the medical aspectsof redox-active drugs, assuming little in the way of prior knowledge.Subsequent sections and chapters describe more specialized aspects of central nervous system injuries, neurodegenerativediseases, pain, radiation injury and radioprotection (such as of brain, lungs, headand neck and erectile function) and neglected diseases (e.g., leishmaniasis).It encompasses several major classes of redox-active experimental therapeutics, whichinclude porphyrins, salens, nitrones, and most notably metal-containing (e.g.,Mn, Fe, Cu, Zn, Sb) drugs as either single compounds or formulations withnanomaterials and quantum dots. Numerous illustrations, tablesand figures enhance and complement the text; extensive references to relevantliterature are also included.
 

Redox-Active Therapeutics is an invaluable addition to Springer’s OxidativeStress in Applied Basic Research and Clinical Practice  series. It is essential reading for researchers, clinicians and graduate studentsinterested in understanding and exploring the Redoxome—the organism redoxnetwork—as an emerging frontier in drug design, redox biology and medicine.
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Specificații

ISBN-13: 9783319307039
ISBN-10: 3319307037
Pagini: 622
Ilustrații: XXX, 694 p. 162 illus., 124 illus. in color.
Dimensiuni: 155 x 235 x 38 mm
Greutate: 1.18 kg
Ediția:1st ed. 2016
Editura: Springer International Publishing
Colecția Springer
Seria Oxidative Stress in Applied Basic Research and Clinical Practice

Locul publicării:Cham, Switzerland

Cuprins

Part1. Pathophysiological Roles of Superoxide Dismutases (SOD).- Superoxide and theSuperoxide Dismutases: An Introduction by Irwin Fridovich.- The Discovery ofSuperoxide Dismutase and Its Role in Redox Biology.- Manganese SuperoxideDismutase (MnSOD) and It's Importance in Mitochondrial Function and Cancer.- Regulationof the Cellular Redox Environment by Superoxide Dismutases, Catalase and GlutathionePeroxidases During Tumor Metastasis.- Superoxide Dismutase Family of Enzymes inBrain Neurogenesis and Radioprotection.- Metabolic Production of H2O2in Carcinogenesis and Cancer Treatment.- Part 2. Redox-Active Therapeutics –Design and Mechanisms of Action.- Mimicking SOD, Why and How: Bio-InspiredManganese Complexes as SOD Mimics.- Mn Porphyrin-Based Redox-ActiveTherapeutics.- Cytochrome P450-like Biomimetic Oxidation Catalysts Based on Mnporphyrins as Redox Modulators.- Nitrones as Potent Anticancer Therapeutics.- SalenManganese Complexes Mitigate Radiation Injury in Normal Tissues ThroughModulation of Tissue Environment.- Molecular Basis for Anticancer and AntiparasiteActivities of Copper-Based Drugs.- Small Signaling Molecules and CO-ReleasingMolecules (CORMs) for the Modulation of the Cellular Redox Metabolism.- HNO/ThiolBiology as a Therapeutic Target.- Part 3. Redox-Active Therapeutics in Cancer.-Advances in Breast Cancer Therapy Using Nitric Oxide and Nitroxyl Donor Agents.-Mechanisms by Which Manganese Porphyrins Affect Signaling in Cancer Cells.- TargetedTherapy for Malignant Brain Tumors.- Redox Therapeutics in Breast Cancer: Role ofSOD Mimics.- Anticancer Action of Mn porphyrins in Head and Neck Cancers.- Redox-basedTherapeutic Strategies in the Treatment of Skin Cancers.- Role of Oxidative Stressin Erectile Dysfunction after Prostate Cancer Therapy.- Theranostic Nanoconjugatesof Tetrapyrrolic Macrocycles and Their Applications in Photodynamic Therapy.-Part 4. Redox-Active Therapeutics in Other Diseases.- QuantumDots inPhotodynamic Therapy.- Metalloporphyrins in CNS injuries.- The Contribution of NitroxidativeStress to Pathophysiological Pain and Opioid Analgesic Failure.- AmyotrophicLateral Sclerosis – Present Understanding of the Role of SOD.- Redox Regulationand Misfolding of SOD1: Therapeutic Strategies for Amyotrophic LateralSclerosis.- Redox-Based Therapeutics for Prevention, Mitigation,and Treatment of Lung Injury Secondary to Radiation Exposure.- Using Metalloporphyrinsto Preserve β Cell Mass and Inhibit Immune Responses in Diabetes.-Redox-Active Metal Complexes in Trypanosomatids.

Notă biografică

INES BATINIC-HABERLE,PhD
Ines Batinic-Haberle is a Professor of RadiationOncology at the Department of Radiation Oncology, Duke University School ofMedicine. She received her B.Sc. in Food Chemistry, M.Sc. degree in AnalyticalChemistry, and her Ph.D. degree in Bioinorganic Chemistry from the School ofPharmacy and Biochemistry, University of Zagreb, Croatia. She completed herpostdoctoral education at the Department of Chemistry, Duke University. She thenmoved to the Department of Biochemistry at Duke University School of Medicine,where she was trained by Irwin Fridovich, the Father of the field of Free Radicals in Biology and Medicine. Shespent 10 years in Fridovich’s Lab where she acquired the basis of her expertisein Oxidative Stress and Redox-Active Therapeutics and launchedthe design of powerful Mn porphyrin-based SOD mimics.  She established the structure-activityrelationship for Mn porphyrin-based SOD mimics, which she subsequently extendedto all classes of SOD mimics. She holds a number of compositional and methodsof use patents on metalloporphyrins; her lead compounds are either already inor entering Clinical Trials in 2016. She authored more than 190 manuscripts,several book chapters, has served as Guest/Invited Editor and reviewer ofvarious prestigious journals and granting agencies both nationally and internationally.For the last 6 years she has served as a Societyfor Redox Biology and Medicine (SFRBM) Officer and is a founding member ofthe Society of Porphyrins andPhthalocyanines. She was recently awarded the SFRBM Excellence in MentoringAward. She has organized numerous Symposia nationally and internationally andgave lectures at numerous Universities in the USA and abroad. She hasestablished numerous collaborations with research groups in USA andinternationally and worked actively in advancing metalloporphyrins towardsclinic.
JULIO S. REBOUCAS, PhD
JulioS. Reboucas is an Adjunct Professor at Universidade Federal da Paraiba (UFPB,Brazil), Adjunct Head of the UFPB Chemistry Graduate Programs, and Fellow ofthe Brazilian National Research Council (CNPq). He received his ChemicalEngineering B.Sc. and Chemistry M.Sc. degrees from Universidade Federal de MinasGerais (Brazil) and his Chemistry Ph.D. degree from the University of BritishColumbia (Canada). He joined the Batinic-Haberle and Spasojevic Laboratories atDuke University (USA) in 2006, where he completed his postdoctoral training in oxidativestress and porphyrin-based redox-active therapeutics, before moving to UFPB in2009 to establish an accredited porphyrin research group. His research spansthe fields of medicinal and inorganic chemistry, with emphasis onporphyrin-based biomimetic systems. He has co-authored 52 manuscripts, two bookchapters, and has one patent application. He is a founding member of the Society of Porphyrins and Phthalocyaninesand currentlyserves as the elected Inorganic Chemistry Division secretary ofthe Brazilian Chemical Society. Amonghis honors and awards is receiving the Young Investigator Award by the Society for Redox Biology and Medicine. Hehas collaborated with various groups within Brazil and abroad on porphyrinchemistry and medicine. 
IVAN SPASOJEVIC, PhD
Ivan Spasojevicis an Assistant Professor of Medicine at the Department of Medicine, Divisionof Oncology. He is also a Director of the PK/PD Core Lab of Duke CancerInstitute Pharmaceutical Research Shared Resource, an NCI-supportedstate-of-the-art bioanalytical facility providing study design and modelingexpertise in pharmacokinetics/pharmacodynamics (PK/PD) and performing analysisof drugs and their metabolites, oxidative stress markers and other smallbiomolecules in general. His Lab has provided the invaluable support in thedevelopment of Mn porphyrins towards Clinical Trials. Ivan earned his B.Sc.degree in Chemical Engineering from the School of Chemical Engineering, Zagreb,Croatia and his Ph.D. Degree in Bioinorganic Chemistry from the Department ofChemistry, Duke University. He completed his postdoctoral training with IrwinFridovich in the field of Oxidative stress and Free Radicals inBiology and Medicine and started his work on the design of Mnporphyrin-based SOD mimics. He has co-authored 126 manuscripts includingseveral Book Chapters, has several compositional and method of use patents andpatent applications. He has served as Guest/Invited Editor and reviewer ofvarious prestigious journals and was invited speaker/organized symposia at Nationaland International Meetings. He is a founding member of the Society ofPorphyrins and Phthalocyanines. He has collaborated with numerous groups inand outside of USA in the field of drug development and pharmacokinetics.

Textul de pe ultima copertă

Thisessential volume comprehensively discusses redox-active therapeutics, focusingparticularly on their molecular design, mechanistic, pharmacological andmedicinal aspects.  The first section of the book describes the basicaspects of the chemistry and biology of redox-active drugs and includes a briefoverview of the redox-based pathways involved in cancer (such as the role ofmitochondria, hydrogen peroxide and endogenous antioxidative defenses) and themedical aspects of redox-active drugs, assuming little in the way of priorknowledge. The second section encompasses several major classes of redox-activeexperimental therapeutics, which include porphyrins, salens, nitrones, andother metal-containing (e.g., Mn, Fe, Cu, Zn, Sb) drugs as either singlecompounds or formulations with nanomaterials and quantum dots. Subsequentsections and chapters describe more specialized aspects of redox-activetherapeutics in clinical disorders, such as cancer, cardiovascular diseases,diabetes, central nervous system injuries, neurodegenerative diseases, pain, radiationinjury and radioprotection (such as of brain, lungs, head and neck and erectilefunction) and neglected diseases (e.g., leishmaniasis). Numerous illustrations, tablesand figures enhance and complement the text; extensive references to relevantliterature are also included.
 

Redox-Active Therapeutics is an invaluable additionto Springer’s Oxidative Stress in Applied Basic Research and ClinicalPractice series.  It is essential reading for researchers, cliniciansand graduate students interested in understanding and exploring theRedoxome—the organism redox network—as an emerging frontier in drug design,redox biology and medicine.

Caracteristici

Reviews the latest literature and developments in this area Explains redox activity in cells that is key to understanding processes like metastasis and mechanisms of actions for therapeutics Written by leaders in their fields Includes supplementary material: sn.pub/extras