Renal Cell Carcinoma: Molecular Targets and Clinical Applications
Editat de Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzeren Limba Engleză Paperback – 23 aug 2016
Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.
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Specificații
ISBN-13: 9781493950638
ISBN-10: 1493950630
Pagini: 631
Ilustrații: XVIII, 613 p. 50 illus., 41 illus. in color.
Dimensiuni: 155 x 235 x 32 mm
Greutate: 0.87 kg
Ediția:Softcover reprint of the original 3rd ed. 2015
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 1493950630
Pagini: 631
Ilustrații: XVIII, 613 p. 50 illus., 41 illus. in color.
Dimensiuni: 155 x 235 x 32 mm
Greutate: 0.87 kg
Ediția:Softcover reprint of the original 3rd ed. 2015
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
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Cuprins
Ch. 1: Targeted Therapy for Metastatic Renal Cell Carcinoma : the First Ten Years; Ch. 2: RCC: Pathologic and Molecular assessment of Targets; Ch. 3: Targeted Therapy for Metastatic Renal Cell Carcinoma : the First Ten Years; Ch. 4: VHL and HIF in clear cell Renal Cell Carcinoma: Molecular Abnormalities and Potential Clinical Applications; Ch. 5: PBRM1: A Critical Subunit of the SWI/SNF Chromatin Remodeling Complex; Ch. 6: Sporadic RCC – Abnormalities in Histone Modifying Genes; 7: Genetic Heterogeneity in Renal Cell Carcinoma: Clinical Implications?; Ch. 8: First-Generation Tyrosine Kinase Inhibitors – Clinical Results; 9: Second Generation Tyrosine Kinase Inhibitors (Pazopanib) in Renal Cell Carcinoma: Current Status; Ch. 10: Third Generation TKIs (Axitinib, Tivozanib) in RCC: enhanced efficacy and diminished toxicity?; Ch. 11: Anti-VEGF and VEGFR monoclonal antibodies in RCC; Ch. 12: PI3-Kinase, Akt, and mTOR Inhibitors in RCC; Ch. 13: Carbonic anhydrase IX & Monoclonal Antibody G250: relevance as a clinical and biologic target in Renal Cell Carcinoma; Ch. 14: EGFR and HER2: Relevance in Renal Cell Carcinoma; Ch. 15: The Role of Hepatocyte Growth Factor Pathway Signaling in Renal Cell Carcinoma; Ch. 16: Development of Resistance to Targeted Therapy: Preclinical Findings and Clinical Relevance; Ch. 17: Development of Combination Therapy with Targeted Agents; Ch. 18: Side Effects ofTargeted Thearpy; Ch. 19: The Role of Targeted Therapy in Special Populations; Ch. 20: Immunotherapy: the Current Role of Cytokines; Ch. 21: Immune Checkpoint Inhibitors (anti-CTLA4, anti PD-1) in RCC; Ch. 22: Vaccines in RCC: Clinical and Biological Relevance; Ch. 23: Development and Incorporation of Biomarkers in RCC Therapeutics; Ch. 24: Molecularly Targeted Staging Strategies in Renal Cell Carcinoma; Ch. 25: Clinical Prognostic Factors in Metastatic Renal Cell Carcinoma; Ch. 26: The Role of Advocacy in Renal Cell Carcinoma
Recenzii
From the book reviews:
“This is an important reference for practicing medical oncologists, urologists, and researchers interested in the biology and therapy of this disease. … This book details the most recent research into the molecular targets of RCC and applications for clinical drug development. … It should be part of libraries for clinicians or basic scientists dealing with RCC. It certainly is an excellent reference for basic and translational scientists and clinicians in this field.” (Jianqing Lin, Doody’s Book Reviews, February, 2015)
“This is an important reference for practicing medical oncologists, urologists, and researchers interested in the biology and therapy of this disease. … This book details the most recent research into the molecular targets of RCC and applications for clinical drug development. … It should be part of libraries for clinicians or basic scientists dealing with RCC. It certainly is an excellent reference for basic and translational scientists and clinicians in this field.” (Jianqing Lin, Doody’s Book Reviews, February, 2015)
Notă biografică
Ronald M Bukowski MD
Emeritus Staff Physician
Cleveland Clinic Taussig Cancer Center
Professor Emeritus of Medicine
CCF Lerner College of Medicine of CWRU
Robert Figlin MD
Professor of Medicine and Biomedical Sciences
Director, Division of Hematology Oncology
Department of Medicine, Cedars-Sinai Medical Center
Associate Director for Academic Programs
Samuel Oschin Comprehensive Cancer Institute
Professor Emeritus of Medicine and Urology
David Geffen School of Medicine at UCLA
Robert Motzer MD
Attending Physician
Department of Medicine
Memorial Sloan-Kettering Cancer Center
Professor of Medicine
Weil Medical College of Cornell University
Emeritus Staff Physician
Cleveland Clinic Taussig Cancer Center
Professor Emeritus of Medicine
CCF Lerner College of Medicine of CWRU
Robert Figlin MD
Professor of Medicine and Biomedical Sciences
Director, Division of Hematology Oncology
Department of Medicine, Cedars-Sinai Medical Center
Associate Director for Academic Programs
Samuel Oschin Comprehensive Cancer Institute
Professor Emeritus of Medicine and Urology
David Geffen School of Medicine at UCLA
Robert Motzer MD
Attending Physician
Department of Medicine
Memorial Sloan-Kettering Cancer Center
Professor of Medicine
Weil Medical College of Cornell University
Textul de pe ultima copertă
The third edition of this critically acclaimed book has updated and expanded the survey of clinical, biological and pathological management of localized and advanced renal cell carcinoma. Internationally renowned editors and contributors explore the latest developments in molecular genetics, focusing on the novel targets that have been discovered in epithelial renal tumors.
Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.
Comprehensive and authoritative, Renal Cell Carcinoma: Molecular Targets and Clinical Applications, Third Edition is the definitive text on the rapidly evolving landscape of experimental therapeutics, written and edited by leaders of the field.
Caracteristici
Thoroughly updated edition focusing on new and recent developments in renal cell carcinoma Provides updated information on the rapidly evolving field of renal cell carcinoma personalized medicine, with an emphasis on novel targets and therapy Discusses the significant amount of new biologic and clinical information such as refinement of the RCC systemic treatment paradigm, immunoregulatory abnormalities in RCC, and adjuvant and neoadjuvant therapy? Includes supplementary material: sn.pub/extras