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Resistance to Targeted Therapies Against Adult Brain Cancers: Resistance to Targeted Anti-Cancer Therapeutics

Editat de Amanda Tivnan
en Limba Engleză Hardback – 16 dec 2016
This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

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Specificații

ISBN-13: 9783319465043
ISBN-10: 331946504X
Pagini: 468
Ilustrații: XVI, 260 p. 19 illus., 16 illus. in color.
Dimensiuni: 155 x 235 x 18 mm
Greutate: 0.57 kg
Ediția:1st ed. 2016
Editura: Springer International Publishing
Colecția Springer
Seria Resistance to Targeted Anti-Cancer Therapeutics

Locul publicării:Cham, Switzerland

Cuprins

Targeted therapies in gliomas: An overview.- Targeting chemotherapy resistance in glioblastoma through modulation of ABC transporters.- Resistance of Glioblastomas to Radiation Therapy.- The blood-brain barrier in glioblastoma multiforme: Pathology and therapeutic implications.- Resistance of brain tumours to small-molecule targeted therapies: lessons from various cancer types.- Drug repurposing to circumvent chemotherapy resistance in brain tumours.- Small molecule inhibitors in glioblastoma: Key pathways and resistance mechanisms.- Imaging Targeted Therapy Response and Resistance in Glioblastoma.- Drug Resistance in Malignant Meningiomas.- Recurrence of Low-Grade Glioma - Have the Targeted Therapies Improved for Better Outcomes?.- Host-Tumor Interactions in Brain Cancer Metastasis Leading to Drug Resistance.


Recenzii

“This is a complete monograph on the molecular and cell biology of 'brain tumors' resistant mechanisms. The book discusses chemotherapy and radiotherapy of brain malignancies including gliomas, ependynomas, and meningiomas. … I highly recommend this book as a reference and research tool for neurosurgeons, oncologists, neurologists, residents, and students.” (Joseph Grenier, Amazon.de, May, 2018)

Notă biografică

Amanda Tivnan, PhD, is Senior Postdoctoral Research Fellow, Department of Physiology and Medical Physics, The Royal College of Surgeons, Dublin, Ireland.

Textul de pe ultima copertă

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

Caracteristici

This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumours This volume will prove as a highly relevant, detailed and up-to-date account of the research and findings in the field of brain cancer research and resistance to currently developed targeted therapies This volume will also contain information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance and state-of-the-art imaging of targeted therapies Includes supplementary material: sn.pub/extras