RGS Protein Physiology and Pathophysiology: Progress in Molecular Biology and Translational Science, cartea 133
Rory A. Fisheren Limba Engleză Hardback – 22 iun 2015
Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery.
The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics.
- Brings together information on the current state of the RGS protein field
- Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking
- Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery
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Specificații
ISBN-13: 9780128029381
ISBN-10: 0128029382
Pagini: 226
Dimensiuni: 152 x 229 x 15 mm
Greutate: 0.52 kg
Editura: ELSEVIER SCIENCE
Seria Progress in Molecular Biology and Translational Science
ISBN-10: 0128029382
Pagini: 226
Dimensiuni: 152 x 229 x 15 mm
Greutate: 0.52 kg
Editura: ELSEVIER SCIENCE
Seria Progress in Molecular Biology and Translational Science
Public țintă
Clinicians and researchers studying the involvement of GPCR signaling in health and disease as well as those specifically interested in the RGS protein family. In addition, the various vignettes planned for this compendium may be of direct interest to those studying cardiovascular, neuropsychiatric and oncological diseases.Cuprins
- Introduction: G Protein-coupled Receptors and RGS Proteins
Adele Stewart and Rory A. Fisher - RGS-insensitive G Proteins as in vivo Probes of RGS Function
Richard R. Neubig - RGS Protein Regulation of Phototransduction
Ching-Kang Jason Chen - Role of Regulators of G Protein Signaling (RGS) Proteins in Bone Physiology and Pathophysiology
Joel Jules, Shuying Yang, Wei Chen and Yi-Ping Li - Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function
Patrick Osei-Owusu and Kendall J. Blumer - Keeping the Balance Right: Regulator of G Protein Signaling 5 in Vascular Physiology and Pathology
Ruth Ganss - Two for the Price of One: G Protein-Dependent and -Independent Functions of RGS6 in vivo
Adele Stewart, Biswanath Maity and Rory A. Fisher - Physiology of RGS10 in Neurons and Immune Cells
Jae-Kyung Lee and Malú G. Tansey - Regulator of G Protein Signaling 14 (RGS14): A Molecular Brake for Synaptic Plasticity Linked to Learning and Memory
Paul R. Evans, Serena M. Dudek and John R. Hepler